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June 17 2006
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How Prozac Works in Your Brain

It has been known for some time that the antidepressant drug Prozac treats depression by causing more brain cells to be born.

However, researchers at the Cold Spring Harbor Laboratory in Long Island, New York have found a previously unknown piece of the puzzle: just how Prozac does this.

The researchers analyzed proteins produced by different cells in the brains of mice and were able to track the steps involved in converting an immature stem cell into a mature, specialized brain cell, or neuron.

They found that Prozac acted on the second step of this process, triggering the production of an immature brain cell called ANPs (amplifying neural progenitors).

ANPs ultimately develop into mature brain cells, which lead to increased numbers of neurons in a region of the brain called the dentate gyrus.

The researchers are testing other antidepressants and new drugs to determine if they have the same effect. They are hoping to identify alternative drugs for depression that may be more potent, or have less side effects, than Prozac, along with new treatments for neurodegenerative diseases such as Alzheimer's disease. 




Dr. Mercola Dr. Mercola's Comments:

One of the amazing methods of marketing is to provide a very complex scientific explanation for why things work. This full-text article from the prestigious Proceedings of the National Academy of Sciences certainly would lead you to believe that Prozac works.

But does it?

Are the changes observed in the study a result of the drug or a belief that it will work? My vote is for the latter and there is some fairly compelling evidence to support that. 

A study in the International Journal of Psychopharmacology showed that the majority of antidepressant trials conducted by drug companies have found that sugar pills, or placebos, produce results similar to -- or better than -- antidepressant drugs. In one study of 96 antidepressant trials conducted between 1979 and 1996, no difference could be determined between the effects of antidepressants and sugar pills in some 52 percent of trials.

This is an important issue as depression is a very serious disorder, and over 15 percent of adults will suffer from depression at some point in their lifetime.

Further, it can be pre-terminal as many people with depression commit suicide. Clearly, this is not something to be taken lightly.

Part of the problem is identifying if you have depression. If you need help in learning if you or someone you love truly has depression then review the first link below, as it extensively reviews how to do this.

Optimizing your diet is clearly an important step in treating depression, and two of the most important parts are to eliminate sugars and make sure you are getting enough omega-3 fats. I have had large numbers of patients spontaneously take themselves off their antidepressants once they started the fish or krill oil, which has been particularly useful in those with depression.

Dr. Stoll, director of the psychopharmacology research lab at Boston's McLean Hospital and assistant professor of psychiatry at Harvard Medical School, discusses this topic extensively in his book The Omega-3 Connection. I highly recommend this book, which reviews evidence supporting the use of omega-3 oils for depression.

However, when it comes to the major player here, it is certainly energetic rebalancing techniques, my favorite of which is EFT. You can review my free, 25-page report that discusses how to perform the EFT technique, however, depression is best treated with a trained EFT therapist. To find an EFT therapist, you can review Gary Craig's EFT Practitioner Referrals.


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