Omega-3 fats are known to ameliorate metabolic risk factors for cardiovascular disease. A recent study investigated the effects of omega-3 fats, given as krill oil, on endocannabinoids, which have been linked to metabolic syndrome.
Mice were fed an unhealthy diet until their endocannabinoid levels were increased in their tissues. After supplementation with omega-3's, levels of endocannabinoid precursors went down.
According to the study:
"[The] data suggest that [krill oil] may promote therapeutic benefit by reducing endocannabinoid precursor availability and hence endocannabinoid biosynthesis."