Health Benefits of CLA

References on Conjugated Linoleic Acid (CLA)
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Adlof RO, Duval S, Emken EA. Biosynthesis of conjugated linoleic acid in humans. Lipids 35:131-135 (2000).

Azain MJ, Hausman DB, Sisk MB, Flatt WP, Jewell DE. Dietary conjugated linoleic acid reduces rat adipose tissue cell size rather than cell number. J. Nutr. 130:1548-1554 (2000).

Basu S, Smedman A, Vessby B. Conjugated linoleic acid induces lipid peroxidation in humans. FEBS Lett. 468(1):33-36 (2000).

Basu S, Riserus U, Turpeinen A, Vessby B. Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clin. Sci. 99(6):511-516 (2000).

Bauman DE, Barbano DM, Dwyer DA, Griinari JM. Technical note: Production of butter with enhanced conjugated linoleic acid for use in biomedical studies with animal models. J. Dairy Sci. 83:2422-2425 (2000).

Bauman, DE, Griinari JM. Regulation and nutritional manipulation of milk fat. In Biology of the Mammary Gland. J. A. Mol and R. A. Clegg (eds.). New York, Kluwer Academic/Plenum Publishers. Pp. 209-216 (2000).

Bauman DE, Griinari JA. Historical perspective and recent developments in identifying the cause of diet-induced milk fat depression. In: Proc. Cornell Nutr. Conf. Feed Manuf. Ithaca, NY: Cornell Nutrition Conference (62nd). Pp. 191-202 (2000).

Baumgard LH, Corl BA, Dwyer DA, Saebo A, Bauman DE. Identification of the conjugated linoleic acid isomer that inhibits milk fat synthesis. Am. J. Physiol. - Regulatory Integrative & Comparative Physiology 278:R179-R184 (2000).

Baumgard LH, Corl BA, Bauman DE. Effect of CLA isomers on fat synthesis during growth and lactation. In: Proc. Cornell Nutr. Conf. Feed Manuf. Ithaca, NY: Cornell Nutrition Conference (62nd). Pp. 180-190 (2000).

Bee G. Dietary conjugated linoleic acids alter adipose tissue and milk lipids of pregnant and lactating sows. J. Nutr. 130:2292-2298 (2000).

Bee G. Dietary conjugated linoleic acid consumption during pregnancy and lactation influences growth and tissue composition in weaned pigs. J. Nutr. 130:2981-2989 (2000).

Behr A, Fiene M, Naendrup F, Schurmann K. Transition-metal trifluoromethane-sulphonates - recyclable catalysts for the synthesis of branched fatty derivatives by Diels-Alder reactions at unsaturated fatty esters. European J. Lipid Sci. Technol. 102:342-350 (2000).

Berven G, Bye A, Hals O, Blankson H, Fagertun H, Thom E, Wadstein J, Gudmundsen O. Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. European J. Lipid Sci. Technol. 102:455-462 (2000).

Bessa RJB, Santos-Silva J, Ribeiro JMR, Portugal AV. Reticulo-rumen biohydrogenation and the enrichment of ruminant edible products with linoleic acid conjugated isomers. Livestock Prod. Sci. 63:201-211 (2000).

Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J. Nutr. 130:2943-2948 (2000).

Buison A, Ordiz F, Pellizzon M, Jen KLC. Conjugated linoleic acid does not impair fat regain but alters IGF-1 levels in weigh-reduced rats. Nutr. Res. 20:1591-1601 (2000).

Cannella C, Giusti AM. Conjugated linoleic acid - A natural anticarcinogenic substance from animal food. Italian J. Food Sci. 12:123-127 (2000).

Casutt MM, Scheeder MRL, Ossowski DA, Sutter F, Sliwinski BJ, Danilo AA, Kreuzer M. Comparative evaluation of rumen-protected fat, coconut oil and various oilseeds supplemented to fattening bulls - 2. Effects on composition and oxidative stability of adipose tissues. Arch. Anim. Nutr. 53:25-44 (2000).

Chilliard Y, Ferlay A, Mansbridge RM, Doreau M. Ruminant milk fat plasticity: nutritional control of saturated, polyunsaturated, trans and conjugated fatty acids. Annal. Zootech. 49:181-205 (2000).

Choi YJ, Kim YC, Han YB, Park Y, Pariza MW, Ntambi JM. The trans-10,cis-12 isomer of conjugated linoleic acid downregulates stearoyl-CoA desaturase 1 gene expression in 3T3-L1 adipocytes. J. Nutr. 130:1920-1924 (2000).

Corl BA, Baumgard LH, Bauman DE. Role of delta-9-desaturase in the synthesis of the anticarcinogenic isomer of CLA and other milk fatty acids. In: Proc. Cornell Nutr. Conf. Feed Manuf. Ithaca, NY: Cornell Nutrition Conference (62nd). Pp. 203-212 (2000).

Cross RF, Ostrowska E, Muralitharan H, Dunshea FR. Mixed mode retention and the use of competing acid for the Ag+-HPLC analysis of underivatized conjugated linoleic acids. J. High Res. Chromatogr. 23:317-323 (2000).

DeLany JP, West DB. Changes in body composition with conjugated linoleic acid. J. Am. Coll. Nutr. 19:487S-493S (2000).

Dhiman TR, Satter LD, Pariza MW, Galli MP, Albright K, Tolosa MX. Conjugated linoleic acid (CLA) content of milk from cows offered diets rich in linoleic and linolenic acid. J. Dairy Sci. 83:1016-1027 (2000).

Dhurandhar NV, Israel BA, Kolesar JM, Mayhew GF, Cook ME, Atkinson RL. Increased adiposity in animals due to a human virus. Int. J. Obesity 24:989-996 (2000).

Ding ST, McNeel RL, Mersmann HJ. Conjugated linoleic acid increases the differentiatino of porcine adipocytes in vitro. Nutr. Res. 20:1569-1580 (2000).

Donovan DC, Schingoethe DJ, Baer RJ, Ryali J, Hippen AR, Franklin ST. Influence of dietary fish oil on conjugated linoleic acid and other fatty acids in milk fat from lactating dairy cows. J. Dairy Sci. 83:2620-2628 (2000).

Du M, Ahn DU, Nam KC, Sell JL. Influence of dietary conjugated linoleic acid on volatile profiles, color and lipid oxidation of irradiated raw chicken meat. Meat Sci. 56(4):387-395 (2000).

Du M, Ahn DU, Sell JL. Effects of dietary conjugated linoleic acid and linoleic : linolenic acid ratio on polyunsaturated fatty acid status in laying hens. Poultry Sci. 79(12):1749-1756 (2000).

Evans M, Geigerman C, Cook J, Curtis L, Kuebler B, McIntosh M. Conjugated linoleic acid suppresses triglyceride accumulation and induces apoptosis in 3T3-L1 preadipocytes. Lipids 35:899-910 (2000).

Flachowsky G. Content of conjugated linoleic acid in beef from organically raised cattle. Ernahrungs-Umschau 47:272 (2000).

French P, Stanton C, Lawless F, O'Riordan EG, Monahan FJ, Caffrey PJ, Moloney AP. Fatty acid composition, including conjugated linoleic acid, of intramuscular fat from steers offered grazed grass, grass silage, or concentrate-based diets. J. Anim. Sci. 78(11):2849-2855 (2000).

Fritsche J, Fritsche S, Solomon MB, Mossoba MM, Yurawecz MP, Morehouse K, Ku Y. Quantitative determination of conjugated linoleic acid isomers in beef fat. European J. Lipid Sci. Technol. 102:667-672 (2000).

Garcia HS, Keough KJ, Arcos JA, Hill CG. Interesterification (acidolysis) of butterfat with conjugated linoleic acid in a batch reactor. J. Dairy Sci. 83(3):371-377 (2000).

Garcia HS, Arcos JA, Ward DJ, Hill CG. Synthesis of glycerides containing n-3 fatty acids and conjugated linoleic acid by solvent-free acidolysis of fish oil. Biotechnol. Bioengineer. 70(5):587-591 (2000).

Gavino VC, Gavino G, Leblanc MJ, Tuchweber B. An isomeric mixture of conjugated linoleic acids but not pure cis-9,trans-11-octadecadienoic acid affects body weight gain and plasma lipids in hamsters. J. Nutr. 130:27-29 (2000).

Gill HS, Cross ML. Anticancer properties of bovine milk Brit. J. Nutr. 84:S161-S166 (Suppl. 1) (2000).

Glaser KR, Scheeder MRL, Wenk C. Dietary C18 : 1 trans fatty acids increase conjugated linoleic acid in adipose tissue of pigs. European J. Lipid Sci. Technol. 102:684-686 (2000).

Griinari JM, Cori BA, Lacy SH, Chouinard PY, Nurmela KVV, Bauman DE. Conjugated linoleic acid is synthesized endogenously in lactating dairy cows by Delta(9)-desaturase. J. Nutr. 130:2285-2291 (2000).

Gulati SK, Kitessa SM, Ashes JR, Fleck E, Byers EB, Byers YG, Scott TW. Protection of conjugated linoleic acids from ruminal hydrogenation and their incorporation into milk fat. Anim. Feed Sci. Technol. 86:139-148 (2000).

Haumann P, Snell H. Influence of keeping method (indoors vs. biotope) on the meat performance of goat kids of different genotypes. Zuchtungskunde 72:308-318 (2000).

Hubbard NE, Lim D, Summers L, Erickson KL. Reduction of murine mammary tumor metastasis by conjugated linoleic acid. Cancer Lett. 150:93-100 (2000).

Igarashi M, Miyazawa T. Newly recognized cytotoxic effect of conjugated trienoic fatty acids on cultured human tumor cells. Cancer Lett. 148:173-179 (2000).

Ip C, Ip MM, Loftus T, Shoemaker S, Shea-Eaton W. Induction of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland. Cancer Epidemiol. Biomarkers Prevent. 9:689-696 (2000).

Jahreis G. Content of conjugated linoleic acid in beef from organically raised cattle. Ernahrungs-Umschau 47:271-272 (2000).

Jahreis G, Kraft J, Tischendorf F, Schone F, von Loeffelholz C. Conjugated linoleic acids: Physiological effects in animal and man with special regard to body composition. European J. Lipid Sci. Technol. 102:695-703 (2000).

Jones DF, Weiss WP, Palmquist DL. Short communication: Influence of dietary tallow and fish oil on milk fat composition. J. Dairy Sci. 83:2024-2026 (2000).

Jones S, Ma DWL, Robinson FE, Field CJ, Clandinin MT. Isomers of conjugated linoleic acid (CLA) are incorporated into egg yolk lipids by CLA-fed laying hens. J. Nutr. 130:2002-2005 (2000).

Jun WJ, Yang HC, Cho BHS. Comparison of conjugated linoleic acid and linoleic acid on cytotoxicity, synthesis, and secretion of lipids in HepG2 cells. In Vitro Mol. Toxicol. 13:181-189 (2000).

Kamlage B, Hartmann L, Gruhl B, Blaut M. Linoleic acid conjugation by human intestinal microorganisms is inhibited by glucose and other substrates in vitro and in gnotobiotic rats. J. Nutr. 130:2036-2039 (2000).

Kelley DS, Taylor PC, Rudolph IL, Benito P, Nelson GJ, Mackey BE, Erickson KL. Dietary conjugated linoleic acid did not alter immune status in young healthy women. Lipids 35(10):1065-1071 (2000).

Kim SJ, Park GB, Kang CB, Park SD, Jung MY, Kim JO, Ha YL. Improvement of oxidative stability of conjugated linoleic acid (CLA) by microencapsulation in cyclodextrins. J. Agric. Food Chem. 48:3922-3929 (2000).

Kim YJ, Liu RH, Bond DR, Russell JB. Effect of linoleic acid concentration on conjugated linoleic acid production by Butyrivibrio fibrisolvens A38. Appl. Environ. Microbiol. 66:5226-5230 (2000).

Kritchevsky D. Antimutagenic and some other effects of conjugated linoleic acid. Br. J. Nutr. 83:459-465 (2000).

Kritchevsky D, Tepper SA, Wright S, Tso P, Czarnecki SK. Influence of conjugated linoleic acid (CLA) on establishment and progression of atherosclerosis in rabbits. J. Am. Coll. Nutr. 19:472S-477S (2000).

Latour MA, Devitt AA, Meunier RA, Stewart JJ, Watkins BA. Effects of conjugated linoleic acid. 1. Fatty acid modification of yolks and neonatal fatty acid metabolism. Poultry Sci. 79:817-821 (2000).

Latour MA, Devitt AA, Meunier RA, Stewart JJ, Watkins BA. Effects of conjugated linoleic acid. 2. Embryonic and neonatal growth and circulating lipids. Poultry Sci. 79:822-826 (2000).

Leung YH, Liu RH. trans-10,cis-12-conjugated linoleic acid isomer exhibits stronger oxyradical scavenging capacity than cis-9,trans-11-conjugated linoleic acid isomer. J. Agric. Food Chem. 48:5469-5475 (2000).

Ledoux M, Laloux L, Sauvant D. Trans fatty acid isomers: origin and occurrence in food. Sci. Aliments 20(4-5):393-411 (2000).

Lin TY. Conjugated linoleic acid concentration as affected by lactic cultures and additives. Food Chem. 69:27-31 (2000).

Livisay SA, Zhou SY, Ip C, Decker EA. Impact of dietary conjugated linoleic acid on the oxidative stability of rat liver microsomes and skeletal muscle homogenates. J. Agric. Food Chem. 48:4162-4167 (2000).

Lucchi L, Banni S, Melis MP, Angioni E, Carta G, Casu V, Rapana R, Ciuffreda A, Corongiu FP, Albertazzi A. Changes in conjugated linoleic acid and its metabolites in patients with chronic renal failure. Kidney Int. 58(4):1695-1702 (2000).

MacDonald HB. Conjugated linoleic acid and disease prevention: A review of current knowledge. J Am Coll Nutr 19(2 Suppl S):111S-118S (2000).

Martin JC, Gregoire S, Siess MH, Genty M, Chardigny JM, Berdeaux O, Juaneda P, Sebedio JL. Effects of conjugated linoleic acid isomers on lipid-metabolizing enzymes in male rats. Lipids 35:91-98 (2000).

McCarty MF. Toward a wholly nutritional therapy for type 2 diabetes. Medical Hypotheses 54(3):483-487 (2000).

McCarty MF. Toward practical prevention of type 2 diabetes.Medical Hypotheses 54(5):786-793 (2000).

McCarty MF. Activation of PPARgamma may mediate a portion of the anticancer activity of conjugated linoleic acid. Medical Hypotheses 55(3):187-188 (2000).

Medina EA, Horn WF, Keim NL, Havel PJ, Benito P, Kelley DS, Nelson GJ, Erickson KL. Conjugated linoleic acid supplementation in humans: Effects on circulating leptin concentrations and appetite. Lipids 35:783-788 (2000).

Mir Z, Rushfeldt ML, Mir PS, et al. Effect of dietary supplementation with either conjugated linoleic acid (CLA) or linoleic acid rich oil on the CLA content of lamb tissues. Small Ruminant Res. 36:25-31(2000).

Mir Z, Paterson LJ, Mir PS. Fatty acid composition and conjugated linoleic acid content of intramuscular fat in crossbred cattle with and without Wagyu genetics fed a barley-based diet. Can. J. Anim. Sci. 80:195-197 (2000).

Molkentin J. Occurrence and biochemical characteristics of natural bioactive substances in bovine milk lipids. Brit. J. Nutr. 84:S47-S53 (Suppl. 1) (2000).

Morales MS, Palmquist DL, Weiss WP. Effects of fat source and copper on unsaturation of blood and milk triacylglycerol fatty acids in Holstein and Jersey cows. J. Dairy Sci. 83:2105-2111 (2000).

Morales MS, Palmquist DL, Weiss WP. Milk fat composition of Holstein and Jersey cows with control or depleted copper status and fed whole soybeans or tallow. J. Dairy Sci. 83:2112-2119 (2000).

Muller HL, Kirchgessner M, Roth FX, Stangl GI. Effect of conjugated linoleic acid on energy metabolism in growing-finishing pigs. J Anim Physiol Anim Nutr 83(2):85-94 (2000).

Nikolova-Damyanova B, Momchilova S, Christie WW. Silver ion high-performance liquid chromatographic separation of conjugated linoleic acid isomers, and other fatty acids, after conversion to p-methoxyphenacyl derivatives. J. High Res. Chromatogr. 23:348-352 (2000).

Ohshita K, Nakajima Y, Yamakoshi J, Kataoka S, Kikuchi M, Pariza MW. Safety evaluation of yeast glutaminase. Food Chem. Toxicol. 38:661-670 (2000).

O'Quinn PR, Andrews BS, Goodband RD, Unruh JA, Nelssen JL, Woodworth JC, Tokach MD, Owen KQ. Effects of modified tall oil and creatine monohydrate on growth performance, carcass characteristics, and meat quality of growing-finishing pigs. J. Anim. Sci. 78:2376-2382 (2000).

O'Quinn PR, Nelssen JL, Goodband RD, Unruh JA, Woodworth JC, Smith JS, Tokach MD. Effects of modified tall oil versus a commercial source of conjugated linoleic acid and increasing levels of modified tall oil on growth performance and carcass characteristics of growing-finishing pigs. J. Anim. Sci. 78:2359-2368 (2000).

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O'Shea M, Devery R, Lawless F, Murphy J, Stanton C. Milk fat conjugated linoleic acid (CLA) inhibits growth of human mammary MCF-7 cancer cells. Anticancer Res. 20(5B):3591-3601 (2000 ).

Ostrowska E, Dunshea FR, Muralitharan M, Cross RF. Comparison of silver-ion high-performance liquid chromatographic quantification of free and methylated conjugated linoleic acids. Lipids 35(10):1147-1153 (2000).

Pardos SC, Torre PD, Sanchez-Muniz FJ. CLA antioxidant or prooxidant Grasas Aceites 51:268-274 (2000).

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Park Y, Allen KGD, Shultz TD. Modulation of MCF-7 breast cancer cell signal transduction by linoleic acid and conjugated linoleic acid in culture. Anticancer Res. 20:669-676 (2000).

Park Y, Storkson JM, Ntambi JM, Cook ME, Sih CJ, Pariza MW. Inhibition of hepatic stearoyl-CoA desaturase activity by trans-10,cis-12 conjugated linoleic acid and its derivatives. Biochim. Biophys. Acta 1486:285-292 (2000).

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