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Historic evidence points to too much aspirin as a contributor to high death tolls during the 1918-1919 flu pandemic.
Most causes of death from influenza are actually the result of pneumonia. Deaths from flu in 1918 were attributable to lung complications, potentially caused by taking too much aspirin.
Aspirin was widely recommended during the 1918 flu pandemic, but taking too much leads to aspirin toxicity. The result is hemorrhage and fluid buildup in the lungs that can lead to death from respiratory complications.