Omega-3 Fats and Glucosamine: Two Arthritis Powerhouses Even Stronger Together

arthritis, osteoarthritis, omega 3, glucosamineNew research shows that omega-3 fats and glucosamine work together to provide additional benefits for people with osteoarthritis.

Scientists gave 1500 mg of glucosamine sulfate to the study participants, but some also received 200 mg of omega-3 fats. Both groups had about the same number of participants who reported a 20 percent or less reduction in pain.

But according to Dr. Christiane Northrup:

“However, when researchers asked those who experienced an 80 percent reduction in pain, those in [the glucosamine plus omega-3 group] reported reduced morning stiffness and pain in the hips and knees by between 48.5 and 55.6 percent, compared to 41.7 to 55.3 percent for those in [the glucosamine only group].”

Dr. Mercola's Comments:

You’ve probably heard that one of the benefits of glucosamine and chondroitin (two animal products marketed as food supplements) is to help relieve symptoms of osteoarthritis. One previous meta-analysis found that glucosamine treatment appears to provide a moderate benefit for osteoarthritis sufferers, and chondroitin treatment provided significant benefit.

But new research indicates there may be a way to significantly boost the benefits of glucosamine – by combining it with omega-3 fats such as fish oil, or my favorite, krill oil.

Supposedly, this is the first study looking at the synergistic effect of these two supplements in combination, and it seems logical that they would provide better pain relief when used together.

Omega-3 is widely recognized for its anti-inflammatory properties, and glucosamine is a precursor for glycosaminoglycans, which are a major component of joint cartilage, which explains why it can help prevent the cartilage degeneration that occurs with osteoarthritis.

What is Osteoarthritis?

Arthritis is a very common health problem that sends over 20 million people to their physician’s office each year. But it’s important to realize that “arthritis” is divided into two primary types: osteoarthritis, also known as degenerative joint disease (DJD); the wear-and-tear form of arthritis, and rheumatoid arthritis (RA).

Osteoarthritis and rheumatoid arthritis are completely different, even though they have some similarities.

They both affect the joints and can be connected with joint stiffness, pain, inflammation and swelling. However, their underlying causes are distinctly different.

Osteoarthritis usually occurs in older individuals, but can also be caused by repetitive stress or acute trauma. Rheumatoid arthritis, on the other hand, can affect you at any age, including children. Fortunately, juvenile rheumatoid arthritis (JRA) is relatively rare.

Understanding the differences between the two types of arthritis will help you distinguish which one you have, and can help you choose between treatment options.

Osteoarthritis – OA is a degenerative joint disease that usually affects the distal joints, or the joints at the end of your fingers and toes, not the middle ones.

Additionally, it’s not symmetrical, so typically you may have it on just one joint, or on one hand or foot and not the other.

If you have osteoarthritis, the cartilage within your joint is progressively being damaged, and the synovial fluid that keeps your joints lubricated and cushioned is typically reduced as well.

The pain is a result of your bones starting to come into contact with each other as cartilage and synovial fluid is reduced.

Rheumatoid arthritis – RA, on the other hand, is an autoimmune disease that causes your body to break itself down. Therefore, it tends to be bilateral and symmetrical, meaning it’s the same on both sides of your body.

If you only have a specific joint affected on one side of your body it’s probably osteoarthritis, not RA.

RA also affects your middle joints, and is associated with joint deformities, especially your hands and fingers. It can be very crippling, and people do die from rheumatoid arthritis, so it’s not something to be treated lightly.

Omega-3 and Glucosamine – A Powerful Combination for Osteoarthritis

I’ve long promoted omega-3 fats for arthritis, whether you have RA or osteoarthritis, because omega-3s are an essential component that your body needs to reduce inflammation, which is present in both. But adding glucosamine to your omega-3s appears to be an excellent choice for osteoarthritis sufferers in particular.

Your body is fully capable of rebuilding cartilage and synovial fluid, but in order to effectively do so it needs the proper building blocks.

In this case, it needs glucosamine to rebuild both cartilage and synovial fluid, so correcting this deficiency by using a high quality supplement can definitely be helpful. Together with the anti-inflammatory properties of omega-3, the pain you experience may be significantly reduced as your condition improves.

In this latest study, participants with moderate-to-severe hip or knee osteoarthritis who received 1,500 mg of glucosamine sulfate along with 200 mg of omega-3 had greater pain reduction and fewer OA symptoms (morning stiffness, pain in hips and knees) than those who took glucosamine by itself.

In her article, Dr. Northrup quotes researcher Joerg Gruenwald, Ph.D. as saying:

“Omega-3 fatty acids inhibit the inflammation process in OA, whereas glucosamine sulfate further supports the rebuilding of lost cartilage substance.”

Other Treatment Options that Work for Both Types of Arthritis

Some of the other treatment methods available are appropriate for both RA and OA, as both involve joint pain, swelling and inflammation. Hence the typical anti-inflammatory approaches such as non-steroidal anti-inflammatories (NSAIDs) and analgesics, like Tylenol, can be used for either.

However, while these can relieve pain – and there’s a lot to be said for pain relief – it’s very important to understand that the regular, chronic use of these types of medications are associated with significant, and very serious, side effects such as kidney and/or liver damage. In the U.S. overuse of analgesics such as these are very common sources of kidney failure.

NSAIDs also kill some 30,000 people every year due to bleeding ulcers, and the oral drugs have been linked to a host of problems, including heart failure -- Vioxx and Celebrex being prime examples of these very real dangers.

This is not to say that they are not useful agents in some cases, but you need to use them very cautiously. This is also why it’s so vital that you seek out the underlying cause of your problem and treat the root cause of RA, so that you can avoid these types of medications to begin with.

Omega-3, as I mentioned earlier, is recommended for either type of arthritis, as it helps prevent inflammation in general.

In addition to that, I also recommend:

Nutritional typing – Your unique biochemistry and genetics influence the ratio of fat, protein and carbohydrates your body needs to thrive, so eating for your nutritional type will ensure that you get the optimal macronutrient ratio out of your diet.

Safe symptomatic approaches for pain -- There are some symptomatic approaches you can use for both conditions. Acupuncture, for example, is a safe and typically effective treatment method for pain.

Herbs and some spices or oils can also be helpful against pain and inflammation. Just remember, they are not treating the cause, only the symptoms.

Here is a list of safe alternatives that may help:

  • Boswellia – Also known as boswellin or "Indian frankincense," this Indian herb is one treatment I’ve found to be particularly useful against arthritic inflammation and associated pain.
  • Ginger – This herb is anti-inflammatory and offers pain relief and stomach-settling properties. Fresh ginger works well steeped in boiling water as a tea or grated into vegetable juice.
  • Bromelain: This enzyme, found in pineapples, is a natural anti-inflammatory. It can be taken in supplement form, but eating fresh pineapple may also be helpful.
  • Cetyl myristoleate (CMO): This oil, found in fish and dairy butter, acts as a "joint lubricant" and an anti-inflammatory.
  • Evening primrose, black currant and borage oils: These contain the essential fatty acid gamma linolenic acid (GLA), which is useful for treating arthritic pain. It is reasonable for many to take these as a supplement, particularly if you struggle with dry skin in the winter, as this is a strong indicator that you are deficient in these fats. I prefer the use of GLA supplements from evening primrose oil but borage oil contains a higher concentration of GLA, which means you need fewer capsules, and it tends to be less expensive.
  • Cayenne Cream: Also called capsaicin cream, this spice comes from dried hot peppers. It alleviates pain by depleting the body's supply of substance P, a chemical component of nerve cells that transmits pain signals to your brain

Address the emotional component of arthritis – I was so pleased to see that Dr. Northrup addressed this issue in her article as well, because it’s such an integral part of a well-rounded treatment plan, although many people will completely overlook it.

In her article, Dr. Northrup writes:

“… the emotional patterns that are associated with and exacerbate osteoarthritic pain are irritation and frustration. The severity of the problem depends upon how intense these emotions are, and how long they’ve been present and unresolved.

Though all of us have irritation and frustration in our lives, there is no need for it to get stuck in our joints and stay there. Recognize when you are feeling irritated or resentful, remind yourself to breathe deeply, and allow yourself to experience these feelings fully without judging yourself.

Movement and sound are powerful ways to change and transform energy of all kinds, so consider dancing and singing, or pounding a pillow while yelling or grunting, to release irritation before it gets caught in your joints.

Don’t allow yourself to carry the irritation of others, either.

Resolving to name and release irritation regularly can take some practice, but when you couple it with a healthy lifestyle, the benefits that result are usually well worth the effort.”


Having an effective method to address the underlying emotional distresses that are present in diseases like OA and RA can be absolutely priceless in terms of disease prevention and/or an effective treatment plan.

In the case of arthritis, often the emotional trauma tends to occur before the age that your conscious mind is formed, which is typically around the age of 5 or 6, though it can happen at any point in your life.

If that specific emotional insult is not addressed with an effective treatment modality, then the underlying emotional trigger will not be removed, allowing the destructive process to proceed.

Therefore, it’s very important to have an effective tool to address these underlying emotional traumas. Dr. Northrup mentioned a few options you could try. My favorite, however, is the Emotional Freedom Technique/Meridian Tapping Technique (EFT/MTT), which is also the most commonly used technique in my clinic.

If you already have OA or RA, your best bet may be to seek out a trained professional to help you with the process.