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The revolutionary science of aging and longevity

Analysis by Dr. Joseph Mercola Fact Checked

Story at-a-glance -

  • Two scientifically demonstrated benefits of fasting are the suppression of mammalian target of rapamycin (mTOR) and the activation of autophagy, both of which play a role in disease prevention and longevity
  • After the age of 30, extrapolations from animal studies suggest the longer you’re able to incorporate some form of regular fasting across your life span, the better
  • When added to a low-calorie diet and healthy lifestyle, NAD boosters such as nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) appear to have a magnifying effect, allowing you to maximize your benefits
  • Sirtuins are proteins that act as environmental stress sensors and are responsible for longevity. Activating sirtuins is one way to increase longevity in yeast and worms. One compound found to activate sirtuins is NAD. Another is resveratrol
  • Research led by David Sinclair, Ph.D., has demonstrated it’s possible to reprogram cells, restoring their original youthfulness, and in so doing, reversing blindness by rejuvenating the nerves in the retina

David Sinclair, Ph.D., is a professor of genetics and co-director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. Generally recognized as one of the thought leaders in the science of how to improve our life span and health span, Sinclair earned his Ph.D. in Sydney, Australia.

After working with Leonard Guarente at Massachusetts Institute of Technology as a postdoctoral researcher, he got his own lab at Harvard in 1999, where he’s been teaching aging biology and translational medicine ever since. Sinclair has also written a book, “Lifespan: Why We Age — and Why We Don’t Have To,” which is scheduled for publication on September 10, 2019.


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