1. Pincus T, Wolfe F: Treatment of Rheumatoid Arthritis: Challenges to Traditional Paradigms. AnnInternMed 115:825-6, Nov 15 1991.

2. Pincus T: Rheumatoid arthritis: disappointing long-term outcomes despite successful short-term clinical trials. J Clin Epidemiol 41:1037-41, 1988.

3. Brooks PM: Clinical management of rheumatoid arthritis. Lancet 341 :286-90, 1993.

4. Pincus T, Callahan LF: Remodeling the pyramid or remodeling the paradigms concerning rheumatoid arthritis - lessons learned from Hodgkin‘s Disease and coronary artery disease. JRheumatol 17:1582-5, 1990.

5. Reah TG: The prognosis of rheumatoid arthritis. Proc R Soc Med 56:813-17, 1963.

6. Wolfe F, Hawley DJ: Remission in rheumatoid arthritis. J Rheumatol 12:245-9, 1985.

7. Kushner I, Dawson NV: Changing perspectives in the treatment of rheumatoid arthritis. JRheumatol 19:1831-34, 1992.

8. Pinals RS: Drug therapy in rheumatoid arthritis a perspective. Br J Rheumatol 28:93-5, 1989.

9. Klippel JH: Winning the battle, losing the war? Another editorial about rheumatoid arthritis. JRheumatol 17:1118-22. 1990.

10. Healey LA, Wilske KR: Evaluating combination drug therapy in rheumatoid arthritis. J Rheumatol 18:641-2, 1991.

11. Wolfe F: 50 Years of antirheumatic therapy: the prognosis of rheumatoid arthritis. J Rheumatol 17:24-32, 1990.

12. Gabriel SE, Luthra HS: Rheumatoid arthritis: Can the long term be altered? Mayo Clin Proc 63:58-68, 1988.

13. Harris ED: Rheumatoid arthritis: Pathophysiology and implications for therapy. NEngl JMed 322:1277-1289, May 3, 1990.

14. Schwartz BD: Infectious agents, immunity and rheumatic diseases. Arthr Rheum 33 :457-465, April 1990.

15. Tan PLJ, Skinner MA: The microbial cause of rheumatoid arthritis: time to dump Koch‘s postulates. J Rheumatol 19:1170-71. 1992.

16. Ford DK: The microbiological causes of rheumatoid arthritis. JRheumatol 18:1441-2, 1991.

17. Burmester GR: Hit and run or permanent hit? Is there evidence for a microbiological cause of rheumatoid arthritis? J Rheumatol 18:1443-7, 1991.

18. Phillips PE: Evidence implications infectious agents in rheumatoid arthritis and juvenile rheumatoid arthritis. Clin EXD Rheumatol 1988 6:87-94.

19. Sabin AB: Experimental proliferative arthritis in mice produced by filtrable pleuropneumonia-like microorganisms. Science 89:228-29, 1939.

20. Swift HF, Brown TMcP: Pathogenic pleuropneumonia-like organisms from acute rheumatic exudates and tissues. Science 89:271-272. 1939.

21. Clark HW, Bailey JS, Brown TMcP: Determination of mycoplasma antibodies in humans. Bacteriol Proc 64:59, 1964.

22. Brown Tmcp, Wichelausen RH, Robinson LB, et al: The in vivo action of aureomycin on pleuropneumonia-like organisms associated with various rheumatic diseases. J Lab Clin Med 34: 1404-1410. 1949.

23. Brown TMcP, Wichelhausen RH: A study of the antigen-antibody mechanism in rheumatic diseases. Amer JMed Sci 221:618, 1951.

24. Brown TMcP: The rheumatic crossroads. Postgrad Med 19:399-402, 1956.

25. Brown TMcP, Clark HW, Bailey JS, et al: Relationship between mycoplasma antibodies and rheumatoid factors. ArthrRheum 13:309-310, 1970.

26. Clark HW, Brown TMcP: Another look at mycoplasma. Arthr Rheum 19:649-50, 1976.

27. Hakkarainen K, et al: Mycoplasmas and arthritis. Ann Rheumat Dis 51: S70-72; l992.

28. Rook, GAW, et al: A reppraisal of the evidence that rheumatoid arthritis and several other idiopathic diseases are slow bacterial infections. Ann Rheum Dis 52:S30-S38; 1993.

29. Clark HW, Coker-Vann MR, Bailey JS, et al: Detection of mycoplasma antigens in immune complexes from rheumatoid arthritis synovial fluids. Ann Allergy 60:394-98, May 1988.

30. Wilder RL: Etiologic considerations in rheumatoid arthritis. Ann Intern Med 101 :820-21, 1984.

31. Bartholomew LE: Isolations and characterization of mycoplasmas (PPLO) from patients with rheumatoid arthritis, systemic lupus erythematosus and Reiter‘s syndrome. Arthr Rheum 8:376-388. 1965.

32. Brown TMcP, et al: Mycoplasma antibodies in synovia. Arthritis Rheum 9:495, 1966.

33. Hernandez LA, Urquhart GED, *** WC: Mycoplasma pneumonia infection and arthritis in man. Br Med J 2: 14- 16. 1977.

34. McDonald MI, Moore JO, Harrelson JM, et al: Septic arthritis due to Mycoplasma hominis. Arth Rheum 26: 1044-47, 1983.

35. Williams MH, Brostoff J, Roitt IM: Possible role of Mycoplasma fermenters in pathogenesis of rheumatoid arthritis. Lancet 2:277-280 1970

36. Jansson E, Makisara P, Vainio K, et al: An 8-year study on mycoplasma in rheumatoid arthritis. Ann Rheum Dis 30:506-508, 1971.

37. Jansson E, Makisara P, Tuuri S: Mycoplasma antibodies in rheumatoid arthritis. Scan J Rheumatol 4: 165-68, 1975.

38. Markham JG, Myers DB: Preliminary observations on an isolate from synovial fluid of patients with rheumatoid arthritis. Ann Rheum Dis, S 1-7 1976.

39. Tully JG, et al: Pathogenic mycoplasmas: cultivation and vertebrate pathogenicity of a new spiroplasma. Science 195:892-4, 1977.

40. Fahlberg WJ, et al: Isolation of mycoplasma from human synovial fluids and tissues. Bacteria Proceedings 66:48-9, 1966.

41. Ponka A: The occurrence and clinical picture of serologically verified Mycoplasma pneumonia infections with emphasis on central nervous system, cardiac and joint manifestations. Ann Clin Res II (suppl) 24, 1979.

42. Hernandez LA, Urquhart GED, *** WC: Mycoplasma pneumonia infections and arthritis in man. Br Med J2:14-16, 1977.

43. Ponka A: Arthritis associated with Mycoplasma pneumonia infection. Scand J Rheumatol 8:27-32, 1979.

44. Stuckey M, Quinn PA, Gelfand EW: Identification of T-Strain mycoplasma in a patient with polyarthritis. Lancet 2:917-920. 1978.

45. Webster ADB, Taylor-Robinson D, Furr PM, et al: Mycoplasmal septic arthritis in hypogammaglobuinemia. Br Med J 1 :478-79, 1978.

46. Ginsburg KS, Kundsin RB, Walter CW, et al: Ureaplasma urealyticum and Mycoplasma hominis in women with systemic lupus erythematosus. Arthritis Rheumatism 35 429-33, 1992.

47. Cole BC, Cassel GH: Mycoplasma infections as models of chronic joint inflammation. Arthr Rheum 22:1375-1381, Dec 1979.

48. Cassell GH, Cole BC: Mycoplasmas as agents of human disease. N Engl J Med 304: 80-89, Jan 8, 1981.

49. Jansson E, et al: Mycoplasmas and arthritis. Rheumatol 42:315-9, 1983.

50. Camon GW, Cole BCC, Ward JR, et al: Arthritogenic effects of Mycoplasma arthritides T cell mitogen in rats. JRheumatol 15:735-41, 1988.

51. Cedillo L, Gil C, Mayagoita G, et al: Experimental arthritis induced by Mycoplasma pneumonia in rabbits. JRheumatol 19:344-7, 1992.

52. Baccala R, Smith LR, Vestberg M, et al: Mycoplasma arthritidis mitogen. Arthritis Rheumatism 35:43442, 1992.

53. Brown McP, Clark HW, Bailey JS: Rheumatoid arthritis in the gorilla: a study of mycoplasma-host interaction in pathogenesis and treatment. In Comparative Pathology of Zoo Animals, RJ Montali, Gigaki (ed), Smithsonian Institution Press. 1980. 259-266.

54. Clark HW: The potential role of mycoplasmas as autoantigens and immune complexes in chronic vascular pathogenesis. Am J Primatol 24:235-243, 1991.

55. Greenwald, rheumatoid arthritis, Goulb LM, Lavietes B, et al: Tetracyclines imibit human synovial collagenase in vivo and in vitro. RhPn fol 14:28-32. 1987.

56. Goulb LM, Lee HM, Lehrer G, et al: Minocycline reduces gingival collagenolytic activity during diabetes. JPeridontRes 18:516-26, 1983.

57. Goulb LM, et al: Tetracyclines imibit comective tissue breakdown: new therapeutic implications for an old family of drugs. Crit Rev Oral Med Pathol 2:297-322, 1991.

58. Ingman T, Sorsa T, Suomalainen K, et al: Tetracycline inhibition and the cellular source of collagenase in gingival revicular fluid in different periodontal diseases. A review article. J Periodontol 64(2):82-8, 1993.

59. Greenwald rheumatoid arthritis, Moak SA, et al: Tetracyclines suppress metalloproteinase activity in adjuvant arthritis and, in combination with flurbiprofen, ameliorate bone damage. J Rheumatol 19:927-38, 1992.

60. Gomes BC, Golub LM, Ramammurthy NS: Tetracyclines inhibit parathyroid hormone induced bone resorption in organ culture. Experientia 40:1273-5, 1985.

61. Yu LP Jr, SMith GN, Hasty KA, et al: Doxycycline inhibits Type XI collagenolytic activity of extracts from human osteoarthritic cartilage and of gelantinase. JRheumatol 18:1450-2, 1991.

62. Thong YH, Ferrante A: Effect of tetracycline treatment of immunological responses in mice. Clin Exp Immunol 39:728-32, 1980.

63. Pruzanski W, Vadas P: Should tetracyclines be used in arthritis? J Rheumatol 19: 1495-6, 1992.

64. Editorial: Antibiotics as biological response modifiers. Lancet 337:400-1, 1991.

65. Van Barr HMJ, et al: Tetracyclines are potent scavengers of the superoxide radical. Br J Dermatol 117:131-4, 1987.

66. Wasil M, Halliwell B, Moorhouse CP: Scavenging of hypochlorous acid by tetracycline, rifampicin and some other antibiotics: a possible antioxidant action of rifampicin and tetracycline? Biochem Pharmacol 37:775-8, 1988.

67. Breedveld FC, Trentham DE: Suppression of collagen and adjuvant arthritis by a tetracycline. Arthritis Rheum 31(1 Supplement)R3, 1988.

68. Trentham, DE; Dynesium-Trentham rheumatoid arthritis: Antibiotic Therapy for Rheumatoid Arthritis: Scientific and Anecdotal Appraisals. Rheum Clin NA 21: 817-834, 1995.

69. Panayi GS, et al: The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum 35:729-35, 1992.

70. Sewell KL, Trentham DE: Pathogenesis of rheumatoid arthritis. Lancet 341 :283-86, 1993.

71. Sewell KE, Furrie E, Trentham DE: The therapeutic effect of minocycline in experimental arthritis. Mechanism of action. JRheumatol 33(suppl):S106, 1991.

72. Panayi GS, Clark B: Minocycline in the treatment of patients with Reiter‘s syndrome. Clin Erp Immunol 7: 100-1, 1989.

73. Pott H-G, Wittenborg A, Junge-Hulsing G: Long-term antibiotic treatment in reactive arthritis. Lancet i:245-6, Jan 30, 1988.

74. Skinner M, Cathcart ES, Mills JA, et al: Tetracycline in the Treatment of Rheumatoid Arthritis. Arthritis and Rheumatism 14:727-732, 1971.

75. Lauhio A, Leirisalo-Repo M, Lahdevirta J, et al: Double-blind placebo-controlled study of three-month treatment with Iymecycline in reactive arthritis, with special reference to Chlamydia arthritis. Arthritis Rheumatism 34:6-14, 1991.

76. Lauhio A, Sorsa T, Lindy O, et al: The anticollagenolytic potential of Iymecycline in the long-term treatment of reactive arthritis. Arthritis Rheumatism 35: 195-198, 1992.

77. Breedveld FC, Dijkmans BCA, Mattie H: Minocycline treatment for rheumatoid arthritis: an open dose finding study. JRheumatol 17:43-46, 1990.

78. Kloppenburg M, Breedveld FC, Miltenburg AMM, et al: Antibiotics as disease modifiers in arthritis. Clin Exper Rheumatol l l(suppl 8):S113-S115, 1993.

79. Langevitz P, et al: Treatment of resistant rheumatoid arthritis with minocycline: An open study. J Rheumatol 19: 1502-04, 1992.

80. Tilley, B, et al: Minocycline in Rheumatoid Arthritis: A 48 week double-blind placebo controlled trial. Ann Intern Med 122:81, 1995.

81. Mills, JA: Do Bacteria Cause Chronic Polyarthritis? N Enel J Med 320:245-246. January 26, 1989.

82. Rothschild BM, et al: Symmetrical Erosive Peripheral Polyarthritis in the Late Archaic Period of Alabama. Science 241:1498-1502, Sept 16, 1988.

83. Clark, HW, et al: Detection of Mycoplasma Antigens in Immune Complexes From Rheumatoid Arthritis Synovial Fluids. Ann Allergy 60:394-398, May 1988.

84. Res PCM, et al: Synovial Fluid T Cell Reactivity Against 65kD Heat Shock Protein of Mycobacteria in Early Chronic Arthritis. Lancet ii:478-480, Aug 27, 1988.

85. Cassell GH, et al: Mycoplasmas as Agents of Human Disease. N Engl J Med 304:80-89, Jan 8, 1981.

86. Breedveld FC, et al: Minocycline Treatment for Rheumatoid Arthritis: An Open Dose Finding Study. J Rheumatol 17:43-46, January 1990.

87. Phillips PE: Evidence implicating infectious agents in rheumatoid arthritis and juvenile rheumatoid arthritis. Clin Exp Rheumatol 6:87-94. 1988.

88. Harris ED: Rheumatoid Arthritis, Pathophysiology and Implications for Therapy. N Engl J Med 322:1277-1289, May 3, 1990.

89. Clark HW: The Potential Role of Mycoplasmas as Autoantigens and Immune Complexes in Chronic Vascular Pathogenesis. Am Jof Primatology 24:235-243. 1991.

90. Silman AJ: Is Rheumatoid Arthritis an Infectious Disease? Br Med J 303:200 July 27, 1991.

91. Clark HW: The Potential Role of Mycoplasmas as Autoantigens and Immune Complexes in Chronic Vascular Pathogenesis. Am J Primatol 24:235-243, 1991.

92. Wheeler HB: Shattuck Lecture Healing and Heroism. NEngl JMed 322:1540-1548, May 24, 1990.

93. Arnett FC: Revised Criteria for the Classification of Rheumatoid Arthritis. Bun Rheum Dis 38:1-6, 1989.

94. Braanan W: Treatment of Chronic Prostatitis. Comparison of Minocycline and Doxycycline. Urology 5:631-636, 1975.

95. Becker FT: Treatment of Tetracycline-Resistant Acne Vulgaris. Cutis 14:610-613. 1974.

96. Cullen, SI: Low-Dose Minocycline Therapy in Tetracycline-Recalcitrant Acne Vulgaris. Cutis 21:101-105, 1978.

97. Mattuccik, et al: Acute Bacterial Sinusitis. Minocycline vs.Amoxicillin. Arch Otolaryngol Head Neck Surgery 112:73-76, 1986.

98. Guillon JM, et al: Minocylcine-induced Cell-mediated Hypersensitivity Pneumonitis. Ann Intern Med 117:476-481, 1992.

99. Gabriel SE, et al: Rifampin therapy in rheumatoid arthritis. J Rheumatol 17: 163-6, 1990.

100. Caperton EM, et al: Cefiriaxone therapy of chronic inflammatory arthritis. Arch Intern Med 150:1677-1682, 1990.

101. Ann Intern Med 117:273-280, 1992.

102. Clive DM, et al: Renal Syndromes Associated with Nonsteroidal Antiinflammatory drugs. NEngl JMed 310:563-572. March 1 l994.

103. Piper, et al: Corticosteroid Use and Peptic Ulcer Disease: Role of Non-Steroidal Anti-inflammatory Drugs. Ann Intern Med 114:735-740, May 1, 1991.

104. Allison MC, et al: Gastrointestinal Damage Associated with the Use of Nonsteroidal Antiinflammatory Drugs. N Engl J Med 327:749-54, 1992.

105. Fries JF:Postmarketing Drug Surveillance: Are Our Priorities Right? JRheumatol 15:389-390, 1988.

106. Brooks PM, et al: Nonsteroidal Antiinflammatory Drugs Differences and Similarities. NEngl JMed 324:1716-1724, June 13, 1991.

107. Agrawal N: Risk Factors for Gastrointestinal Ulcers Caused by Nonsteroidal Anti-inflammatory Drugs (NSAIDs). J Fam Prac 32:619-624, June 1991.

108. Silverstein, F: Nonsteroidal Anti-Inflammatory Drugs and Peptic Ulcer Disease. Postgrad Med 89:33-30, May 15, 1991.

109. Gabriel SE, et al: Risk for Serious Gastrointestinal Complications Related to Use of NSAIDs. Ann Intern Med 115:787-796 1991.

110. Fries JF, et al: Toward an Epidemiology of Gastropathy Associated With NSAID Use. Gastroent 96:647-55, 1989.

111. Armstrong CP, et al: NSAIDs and Life Threatening Complications of Peptic Ulceration. Gut 28:527-32, 1987.

112. Murray MD, et al: Adverse Effects of Nonsteroidal Anti-Inflammatory Drugs on Renal Function. AnnInternMed 112:559, April 15, 1990.

113. Cook DM: Safe Use of Glucocorticoids: How to Monitor Patients Taking These Potent Agents. Postgrad Med 91:145-154, Feb. 1992.

114. Piper JM, et al: Corticosteroid Use and Peptic Ulcer Disease: Role of Nonsteroidal Anti-inflammatory Drugs. Ann Intern Med 114:735-740, May 1, 1991.

115. Thompson JM: Tension Myalgia as a Diagnosis at the Mayo Clinic and Its Relationship to Fibrositis, Fibromyalgia, and Myofascial Pain Syndrome. Mayo Clin Proc 65:1237-1248, September 1990.

116. Semble EL, et al: Therapeutic Exercise for Rheumatoid Arthritis and Osteoarthritis. Seminars in Arthritis and Rheumatism 20:32-40, August 1990.

117. O‘Dell, J, Haire, C, Palmer, W, Drymalski, W, Wees, S, Blakely, K, Churchill, M, Eckhoff, J, Weaver, A, Doud, D, Erickson, N, Dietz, F, Olson, R, Maloney, P, Klassen, L, Moore, G, Treatment of Early Rheumatoid Arthritis with Minocycline or Placebo: Results of a Randomized, Double-Blind, Placebo-Controlled Trial, Arthritis & Rheumatism, 1997, 40:5, 842-848.

118. Tilley, BC, Alarcón, GS, Heyse, SP, Trentham, DE, Neuner, R, Kaplan, DA, Clegg, DO, Leisen, JCC, Buckley, L, Cooper, SM, Duncan, H, Pillemer, SR, Tuttleman, M, Fowler, SE, Minocycline in Rheumatoid Arthritis: A 48-Week, Double-Blind, Placebo-Controlled Trial, Annals of Internal Medicine, 1995, 122:2, 81-89.

119. Bluhm, GB, Sharp, JT, Tilley, BC, Alarcon, GS, Cooper, SM, Pillemer, SR, Clegg, DO, Heyse, SP, Trentham, DE, Neuner, R, Kaplan, DA, Leisen, JC, Buckley, L, Duncan, H, Tuttleman, M, Shuhui, L, Fowler, SE, Radiographic Results from the Minocycline in Rheumatoid Arthritis (MIRA) Trial, Journal of Rheumatology, 1997, 24:7, 1295-1302.

120. Breedveld, FC, Editorial: Minocycline in Rheumatoid Arthritis, Arthritis & Rheumatism, 1997, 40:5, 794-796.

121. Breedveld, FC, Letters: Reply to Minocycline-Induced Autoimmune Disease, Arthritis & Rheumatism, 1998, 41:3, 563-564.

122. Fox, R, Sharp, D, Editorial: Antibiotics as Biological Response Modifiers, The Lancet, 1991, 337:8738, 400-401.

123. Greenwald, rheumatoid arthritis, Golub, LM, Lavietes, B, Ramamurthy, NS, Gruber, B, Laskin, RS, McNamara, TF, Tetracyclines Inhibit Human Synovial Collagenase In Vivo and In Vitro, Journal of Rheumatology, 1987, 14:1, 28-32.

124. Griffiths, B, Gough, A, Emery, P, Letters: Minocycline-Induced Autoimmune Disease: Comment on the Editorial by Breedveld, Arthritis & Rheumatism, 1998, 41:3, 563.

125. Kloppenburg, M, Breedveld, FC, Miltenburg, AMM, Dijkmans, BAC, Antibiotics as Disease Modifiers in Arthritis, Clinical and Experimental Rheumatology, 1993, 11: Suppl. 8, S113-S115.

126. Kloppenburg, M, Breedveld, FC, Terwiel, JPh, Mallee, C, Dijkmans, BAC, Minocycline in Active Rheumatoid Arthritis: A Double-Blind, Placebo-Controlled Trial, Arthritis & Rheumatism, 1994, 37:5, 629-636.

127. Kloppenburg, M, Mattie, H, Douwes, N, Dijkmans, BAC, Breedveld, FC, Minocycline in the Treatment of Rheumatoid Arthritis: Relationship of Serum Concentrations to Efficacy, Journal of Rheumatology, 1995, 22:4, 611-616.

128. Lauhio, A, Leirisalo-Repo, M, Lähdevirta, J, Saikku, P, Repo, H, Double-Blind, Placebo-Controlled Study of Three-Month Treatment with Lymecycline in Reactive Arthritis, with Special Reference to Chlamydia Arthritis, Arthritis & Rheumatism, 1991, 34:1, 6-14.

129. Lauhio, A, Sorsa, T, Lindy, O, Suomalainen, K, Saari, H, Golub, LM, Konttinen, YT, The Anticollagenolytic Potential of Lymecycline in the Long-Term Treatment of Reactive Arthritis, Arthritis & Rheumatism, 1992, 35:2, 195-198.

130. Paulus, HE, Editorial: Minocycline Treatment of Rheumatoid Arthritis, Annals of Internal Medicine, 1995, 122:2, 147-148.

131. Pruzanski, W, Vadas, P, Editorial: Should Tetracyclines be Used in Arthritis?, Journal of Rheumatology, 1992, 19:10, 1495-1497.

132. Sieper, J, Braun, J, Editorial: Treatment of Reactive Arthritis with Antibiotics, British Journal of Rheumatology, July 1998.

133. Baseman, JB, Tully, JG, Mycoplasmas: Sophisticated, Reemerging, and Burdened by Their Notoriety, CDC‘s Emerging Infectious Diseases, 1997, 3:1, 21-32.

134. Franz, A, Webster, ADB, Furr, PM, Taylor-Robinson, D, Mycoplasmal Arthritis in Patients with Primary Immunoglobulin Deficiency: Clinical Features and Outcome in 18 Patients, British Journal of Rheumatology, 1997, 36:6, 661-668.

135. Hakkarainen K, Turunen, H, Miettinen, A, Karppelin, M, Kaitila, K, Jansson, E, Mycoplasmas and Arthritis, Annals of Rheumatic Diseases, 1992, 51, 1170-1172.

136. Hoffman, RH, Wise, KS, Letters: Reply to Mycoplasmas in the Joints of Patients with Rheumatoid Arthritis and Other Inflammatory Rheumatic Disorders, Arthritis & Rheumatism, 1998, 41:4, 756-757.

137. Schaeverbeke, T, Bébéar, C, Lequen, L, Dehais, J, Bébéar, C, Letters: Mycoplasmas in the Joints of Patients with Rheumatoid Arthritis and Other Inflammatory Rheumatic Disorders: Comment on the Article by Hoffman et al., Arthritis & Rheumatism, 1998, 41:4, 754-756.

138. Schaeverbeke, T, Gilroy, CB, Bébéar, C, Dehais, J, Taylor-Robinson, D, Mycoplasma fermentans, But Not M penetrans, Detected by PCR Assays in Synovium from Patients with Rheumatoid Arthritis and Other Rheumatic Disorders, Journal of Clinical Pathology, 1996, 49, 824-828.

139. Aoki, S, Yoshikawa, K, Yokoyama, T, Nonogaki, T, Iwasaki, S, Mitsui, T, Niwa, S, Role of Enteric Bacteria in the Pathogenesis of Rheumatoid Arthritis: Evidence for Antibodies to Enterobacterial Common Antigens in Rheumatoid Sera and Synovial Fluids, Annals of Rheumatic Diseases, 1996, 55:6, 363-369.

140. Blankenberg-Sprenkels, SHD, Fielder, M, Feltkamp, TEW, Tiwana, H, Wilson, C, Ebringer, A, Antibodies to Klebsiella pneumoniae in Dutch Patients with Ankylosing Spondylitis and Acute Anterior Uveitis and to Proteus mirabilis in Rheumatoid Arthritis, Journal of Rheumatology, 1998, 25:4, 743-747.

141. Ebringer, A, Ankylosing Spondylitis is Caused by Klebsiella: Evidence from Immunogenetic, Microbiologic, and Serologic Studies, Rheumatic Disease Clinics of North America, 1992, 18:1, 105-121.

142. Erlacher, L, Wintersberger, W, Menschik, M, Benke-Studnicka, A, Machold, K, Stanek, G, Söltz-Szöts, J, Smolen, J, Graninger, W, Reactive Arthritis: Urogenital Swab Culture is the Only Useful Diagnostic Method for the Detection of the Arthritogenic Infection in Extra-Articularly Asymptomatic Patients with Undifferentiated Oligoarthritis, British Journal of Rheumatology, 1995, 34:9, 838-842.

143. Gaston, JSH, Deane, KHO, Jecock, RM, Pearce, JH, Identification of 2 Chlamydia trachomatis Antigens Recognized by Synovial Fluid T Cells from Patients with Chlamydia Induced Reactive Arthritis, Journal of Rheumatology, 1996, 23:1, 130-136.

144. Gerard, HC, Branigan, PJ, Schumacher Jr, HR, Hudson, AP, Synovial Chlamydia trachomatis in Patients with Reactive Arthritis/ Reiter‘s Syndrome Are Viable But Show Aberrant Gene Expression, Journal of Rheumatology, 1998, 25:4, 734-742.

145. Granfors, K, Do Bacterial Antigens Cause Reactive Arthritis?, Rheumatic Disease Clinics of North America, 1992, 18:1, 37-48.

146. Granfors, K, Merilahti-Palo, R, Luukkainen, R, Möttönen, T, Lahesmaa, R, Probst, P, Märker-Hermann, E, Toivanen, P, Persistence of Yersinia Antigens in Peripheral Blood Cells from Patients with Yersinia Enterocolitica 0:3 Infection with or without Reactive Arthritis, Arthritis & Rheumatism, 1998, 41:5, 855-862.

147. Inman, RD, The Role of Infection in Chronic Arthritis, Journal of Rheumatology, 1992, 19, Supplement 33, 98-104.

148. Layton, MA, Dziedzic, K, Dawes, PT, Letters to the Editor: Sacroiliitis in an HLA B27-negative Patient Following Giardiasis, British Journal of Rheumatology, 1998, 37:5, 581-583.

149. Mäki-Ikola, O, Lehtinen, K, Granfors, K, Similarly Increased Serum IgA1 and IgA2 Subclass Antibody Levels against Klebsiella pneumoniæ Bacteria in Ankylosing Spondylitis Patients With/Without Extra-Articular Features, British Journal of Rheumatology, 1996, 35:2, 125-128.
150. Morrison, RP, Editorial: Persistent Chlamydia trachomatis Infection: In Vitro Phenomenon or in Vivo Trigger of Reactive Arthritis?, Journal of Rheumatology, 1998, 25:4, 610-612.

151. Mousavi-Jazi, M, Boström, L, Lövmark, C, Linde, A, Brytting, M, Sundqvist, V-A, Infrequent Detection of Cytomegalovirus and Epstein-Barr Virus DNA in Synovial Membrane of Patients with Rheumatoid Arthritis, Journal of Rheumatology, 1998, 25:4, 623-628.

152. Nissilä, M, Lahesmaa, R, Leirisalo-Repo, M, Lehtinen, K, Toivanen, P, Granfors, K, Antibodies to Klebsiella pneumoniæ, Escherichia coli, and Proteus mirabilis in Ankylosing Spondylitis: Effect of Sulfasalazine Treatment, Journal of Rheumatology, 1994, 21:11, 2082-2087.

153. Svenungsson, B, Editorial Review: Reactive Arthritis, International Journal of STD & AIDS, 1995, 6:3, 156-160.

154. Tani, Y, Tiwana, H, Hukuda, S, Nishioka, J, Fielder, M, Wilson, C, Bansal, S, Ebringer, A, Antibodies to Klebsiella, Proteus, and HLA-B27 Peptides in Japanese Patients with Ankylosing Spondylitis and Rheumatoid Arthritis, Journal of Rheumatology, 1997, 24:1, 109-114.

155. Tiwana, H, Walmsley, RS, Wilson, C, Yiannakou, JY, Ciclitira, PJ, Wakefield, AJ, Ebringer, A, Characterization of the Humoral Immune Response to Klebsiella Species in Inflammatory Bowel Disease and Ankylosing Spondylitis, British Journal of Rheumatology, 1998, 37:5, 525-531.

156. Wilkinson, NZ, Kingsley, GH, Sieper, J, Braun, J, Ward, ME, Lack of Correlation Between the Detection of Chlamydia trachomatis DNA in Synovial Fluid from Patients with a Range of Rheumatic Diseases and the Presence of an Antichlamydial Immune Response, Arthritis & Rheumatism, 1998, 41:5, 845-854.

157. Wollenhaupt, J, Kolbus, F, Weißbrodt, H, Schneider, C, Krech, T, Zeidler, H, Manifestations of Chlamydia Induced Arthritis in Patients with Silent Versus Symptomatic Urogenital Chlamydial Infection, Clinical and Experimental Rheumatology, 1995, 13:4, 453-458.

158. Alarcon, GS, Tilley, B, Cooper, S, Clegg, DO, Trentham, DE, Pillemer, SR, Neuner, R, Fowler, S, Letter: Another look at minocycline, Bulletin on the Rheumatic Diseases, 1996, 45(8), 6-7.

159. Amin, AR, Attur, MG, Thakker, GD, Patel, PD, Vyas, PR, Patel, RN, Patel, IR, Abramson, SB, A novel mechanism of action of tetracyclines: effects on nitric oxide synthases, Proceedings of the National Academy of Sciences of the United States of America, 1996, 93(24), 14014-14019.

160. Ayuzawa, S, Yano, H, Enomoto, T, Kobayashi, H, Nose, T, The Bi-Digital O-Ring Test used in the successful diagnosis & treatment (with antibiotic, anti-viral agents & oriental herbal medicine) of a patient suffering from pain & weakness of an upper extremity & Barre-Lieou syndrome appearing after whiplash injury: A case report, Acupuncture & Electro-Therapeutics Research, 1997, 22(3-4), 167-174.

161. Bitar, CN, Steele, RW, Use of prophylactic antibiotics in children, Advances in Pediatric Infectious Diseases, 1995, 10, 227-262.

162. Bluhm, GB, Sharp, JT, Tilley, BC, Alarcon, GS, Cooper, SM, Pillemer, SR, Clegg, DO, Heyse, SP, Trentham, DE, Neuner, R, Kaplan, DA, Leisen, JC, Buckley, L, Duncan, H, Tuttleman, M, Li, S, Fowler, SE, Radiographic Results from the Minocycline in Rheumatoid Arthritis (MIRA) Trial, Journal of Rheumatology, 1997, 24(7), 1295-1302.

163. Brandt, KD, Modification by oral doxycycline administration of articular cartilage breakdown in osteoarthritis, Journal of Rheumatology, 1995, Supplement 43, 149-151.

164. Breedveld, FC, Editorial: Minocycline in Rheumatoid Arthritis, Arthritis & Rheumatism, 1997, 40(5), 794-796.

165. Breedveld, FC, Letters: Reply to Minocycline- Induced Autoimmune Disease, Arthritis & Rheumatism, 1998, 41(3), 563-564.

166. Bullingham, R, Shah, J, Goldblum, R, Schiff, M, Effects of food and antacid on the pharmacokinetics of single doses of mycophenolate mofetil in rheumatoid arthritis patients, British Journal of Clinical Pharmacology, 1996, 41(6), 513-516.

167. Burton, IE, Moussa, KM, Sanders, PA, Agranulocytosis in rheumatoid arthritis associated with long-term flucloxacillin for staphylococcal osteomyelitis, Acta Haematologica, 1995, 94(4), 196-198.

168. Canvin, JM, Madhok, R, Letter: Minocycline in rheumatoid arthritis, Annals of Internal Medicine, 1995, 123(5), 392.

169. Caruso, I, Twenty years of experience with intra-articular rifamycin for chronic arthritides, Journal of International Medical Research, 1997, 25(6), 307-317.

170. Currie, BJ, Are the currently recommended doses of benzathine penicillin G adequate for secondary prophylaxis of rheumatic fever?, Pediatrics, 1996, 97(6, Page 2), 989-991.

171. Ebell, MH, Minocycline for rheumatoid arthritis, Journal of Family Practice, 1995, 40(5), 497-498.

172. Elkayam, O, Yaron, M, Zhukovsky, G, Segal, R, Caspi, D, Toxicity profile of dual methotrexate combinations with gold, hydroxychloroquine, sulphasalazine and minocycline in rheumatoid arthritis patients, Rheumatology International, 1997, 17(2), 49-53.

173. Evdoridou, J, Roilides, E, Bibashi, E, Kremenopoulos, G, Multifocal osteoarthritis due to Candida albicans in a neonate: serum level monitoring of liposomal amphotericin B and literature review, Infection, 1997, 25(2), 112-116.

174. Galland, L, Letter: Minocycline and rheumatoid arthritis revisited, Annals of Internal Medicine, 1995, 123(5), 392-393.

175. Griffiths, B, Gough, A, Emery, P, Letters: Minocycline- Induced Autoimmune Disease: Comment on the Editorial by Breedveld, Arthritis & Rheumatism, 1998, 41(3), 563.

176. Hanemaaijer, R, Sorsa, T, Konttinen, YT, Ding, Y, Sutinen, M, Visser, H, van Hinsbergh, VW, Helaakoski, T, Kainulainen, T, Ronka, H, Tschesche, H, Salo, T, Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells: Regulation by tumor necrosis factor-alpha and doxycycline, Journal of Biological Chemistry, 1997, 272(50), 31504-31509.

177. Herdy, GV, Editorial: The challenge of secondary prophylaxis in rheumatic fever [Portuguese, Original Title: Desafio da profilaxia secundaria na febre reumatica, Arquivos Brasileiros de Cardiologia, 1996, 67(5), 317.

178. Herdy, GV, Souza, DC, Barros, PB, Pinto, CA, Secondary prophylaxis in rheumatic fever: Oral antibiotic therapy versus benzathine penicillin [Portuguese, Original Title: Profilaxia secundaria na febre reumatica: Antibioticoterapia oral versus penicilina benzatina], Arquivos Brasileiros de Cardiologia, 1996, 67(5), 331-333.

179. Herrick, AL, Grennan, DM, Griffen, K, Aarons, L, Gifford, LA, Lack of interaction between flucloxacillin and methotrexate in patients with rheumatoid arthritis, British Journal of Clinical Pharmacology, 1996, 41(3), 223-227.

180. Houck, HE, Kauffman, CL, Casey, DL, Minocycline treatment for leukocytoclastic vasculitis associated with rheumatoid arthritis, Archives of Dermatology, 1997, 133(1), 15-16.

181. Iwata, M, Ida, M, Oda, S, Takeuchi, E, Nakamura, Y, Horiguchi, T, Sato, A, Bronchiolitis obliterans preceding rheumatoid arthritis: effect of clarithromycin [Japanese], Nippon Kyobu Shikkan Gakkai Zasshi ^Ö Japanese Journal of Thoracic Diseases, 1996, 34(11), 1271-1276.

182. Kassem, AS, Zaher, SR, Abou Shleib, H, el-Kholy, AG, Madkour, AA, Kaplan, EL, Rheumatic fever prophylaxis using benzathine penicillin G (BPG): two- week versus four-week regimens: comparison of two brands of BPG, Pediatrics, 1996, 97(6, Page 2), 992-995.

183. Kim, NM, Freeman, CD, Minocycline for rheumatoid arthritis, Annals of Pharmacotherapy, 1995, 29(2), 186-187.

184. Kloppenburg, M, Dijkmans, BA, Breedveld, FC, Antimicrobial therapy for rheumatoid arthritis, Baillieres Clinical Rheumatology, 1995, 9(4), 759-769.

185. Kloppenburg, M, Dijkmans, BA, Verweij, CL, Breedveld, FC, Inflammatory and immunological parameters of disease activity in rheumatoid arthritis patients treated with minocycline, Immunopharmacology, 1996, 31(2-3), 163-169.

186. Kloppenburg, M, Mattie, H, Douwes, N, Dijkmans, BA, Breedveld, FC, Minocycline in the treatment of rheumatoid arthritis: relationship of serum concentrations to efficacy, Journal of Rheumatology, 1995, 22(4), 611-616.

187. Kuznetsova, SM, Petrova, NK, Lecture: Antibiotics in the prevention of rheumatic fever [Russian, Original Title: Antibiotiki v profilaktike revmatizma (lektsiia)], Antibiotiki i Khimioterapiia, 1996, 41(2), 43-51.

188. Lai, NS, Lan, JL, Treatment of DMARDs-resistant rheumatoid arthritis with minocycline: a local experience among the Chinese, Rheumatology International, 1998, 17(6), 245-247.

189. Langevitz, P, Livneh, A, Bank, I, Pras, M, Minocycline in rheumatoid arthritis, Israel Journal of Medical Sciences, 1996, 32(5), 327-330.

190. Lauhio, A, Salo, T, Tjaderhane, L, Lahdevirta, J, Golub, LM, Sorsa, T, Letter: Tetracyclines in treatment of rheumatoid arthritis, The Lancet, 1995, 346(8975), 645-646.

191. McKendry, RJ, Is rheumatoid arthritis caused by an infection?, The Lancet, 1995, 345(8961), 1319-1320.

192. Meehan, R, Letter: Minocycline in rheumatoid arthritis, Annals of Internal Medicine, 1995, 123(5), 391-392.

193. Nordstrom, D, Lindy, O, Lauhio, A, Sorsa, T, Santavirta, S, Konttinen, YT, Anti-collagenolytic mechanism of action of doxycycline treatment in rheumatoid arthritis, Rheumatology International, 1998, 17(5), 175-180.

194. O‘Dell, JR, Haire, CE, Palmer, W, Drymalski, W, Wees, S, Blakely, K, Churchill, M, Eckhoff, PJ, Weaver, A, Doud, D, Erikson, N, Dietz, F, Olson, R, Maloley, P, Klassen, LW, Moore, GF, Treatment of Early Rheumatoid Arthritis with Minocycline or Placebo: Results of a Randomized, Double- Blind, Placebo- Controlled Trial, Arthritis & Rheumatism, 1997, 40(5), 842-848.

195. Panush, RS, Thoburn, R, Should minocycline be used to treat rheumatoid arthritis?, Bulletin on the Rheumatic Diseases, 1996, 45(2), 2-5.

196. Patmas, MA, Letter: Minocycline in rheumatoid arthritis, Annals of Internal Medicine, 1995, 123(5), 391-392.

197. Paulus, HE, Editorial: Minocycline treatment of rheumatoid arthritis, Annals of Internal Medicine, 1995, 122(2), 147-148.

198. Pillemer, SR, Fowler, SE, Tilley, BC, Alarcon, GS, Heyse, SP, Trentham, DE, Neuner, R, Clegg, DO, Leisen, JC, Cooper, SM, Duncan, H, Tuttleman, M, Meaningful improvement criteria sets in a rheumatoid arthritis clinical trial: MIRA Trial Group, Minocycline in Rheumatoid Arthritis, Arthritis & Rheumatism, 1997, 40(3), 419-425.

199. Ryan, ME, Greenwald, rheumatoid arthritis, Golub, LM, Potential of tetracyclines to modify cartilage breakdown in osteoarthritis, Current Opinion in Rheumatology, 1996, 8(3), 238-247.

200. Sieper, J, Braun, J, Editorial: Treatment of Reactive Arthritis with Antibiotics, British Journal of Rheumatology, 1998, 37(7), 717-720.

201. Smith, GN Jr, Yu, LP Jr, Brandt, KD, Capello, WN, Oral administration of doxycycline reduces collagenase and gelatinase activities in extracts of human osteoarthritic cartilage, Journal of Rheumatology, 1998, 25(3), 532-535.

202. Tilley, BC, Alarcon, GS, Heyse, SP, Trentham, DE, Neuner, R, Kaplan, DA, Clegg, DO, Leisen, JC, Buckley, L, Cooper, SM, Duncan, H, Pillemer, SR, Tuttleman, M, Fowler, SE, Minocycline in rheumatoid arthritis: A 48-week, double-blind, placebo-controlled trial, MIRA Trial Group, Annals of Internal Medicine, 1995, 122(2), 81-89.

203. Trentham, DE, Dynesius-Trentham, rheumatoid arthritis, Antibiotic therapy for rheumatoid arthritis: Scientific and anecdotal appraisals, Rheumatic Diseases Clinics of North America, 1995, 21(3), 817-834.

204. Wilson, C, Senior, BW, Tiwana, H, Caparros-Wanderley, W, Ebringer, A, Antibiotic sensitivity and proticine typing of Proteus mirabilis strains associated with rheumatoid arthritis, Rheumatology International, 1998, 17(5), 203-205.

205. Yu, LP Jr, Burr, DB, Brandt, KD, O‘Connor, BL, Rubinow, A, Albrecht, M, Effects of oral doxycycline administration on histomorphometry and dynamics of subchondral bone in a canine model of osteoarthritis, Journal of Rheumatology, 1996, 23(1), 137-142.

Presented at the 32nd International Congress of the Great Lakes College of Clinical Medicine. Baltimore, Maryland, September 25, 1999

Dr. Joseph M. Mercola