Canadian researchers have apparently identified a gene that can predict the severity of rheumatoid arthritis (RA). This discovery could possibly lead to earlier treatment and maybe even a cure for the debilitating joint disorder, according to the authors.

• The research focused on the IFN gamma gene, which is important in controlling the body's immune system, and found that the severity of a person's RA depends on differences found in it.

• According to Dr. Abbas Khani-Hanjani of the Immunology Laboratory at Vancouver General Hospital "It is the most powerful indicator currently recognized for predicting the severity of rheumatoid arthritis".

• The discovery may enable doctors to refine their treatment efforts at an early stage when symptoms are still mild, preventing the destruction of cartilage, bone, tendons, and ligaments, which can lead to severe deformity and debilitating pain.

"The discovery of the gene helps us better understand the cause of rheumatoid arthritis and could lead to new treatment options and even a possible cure," said Dr. John Esdaile, scientific director at the Arthritis Research Center in Canada.

Rheumatoid arthritis is a disorder of the immune system, which causes it to attack the lining of joints, resulting in painful inflammation and joint damage.

The Lancet September 2, 2000