Foods Cooked at High Heat Linked to Inflammation
November 30, 2002
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Nutrients aside, cooking food at high temperatures may create health risks. Moreover, people with diabetes who ate foods cooked at relatively low temperatures had reduced levels of inflammation, which is associated with heart disease, in the body, according to a recent study.
When foods are cooked at high temperatures, advanced glycation end products (AGEs) are produced. These compounds, which stimulate cells to produce proteins that cause inflammation, can be toxic to the body. AGEs are normally produced at a slow rate, but the rate increases when food is highly heated.
Twenty-four patients with diabetes were given one of two diets. The diets were identical except for the temperatures at which the foods were cooked. The levels of AGEs in the foods corresponded with the temperatures at which the food was cooked. People who consumed foods cooked at lower temperatures had lower levels of both AGEs and inflammatory proteins than people who consumed the same foods cooked at higher temperatures. Additionally, blood levels of AGEs rose by close to 65 percent among those who consumed the highly heated diet and decreased by 30 percent in those who consumed the low-heat diet after a two-week period.
After six weeks, people who consumed the high AGE diet had increased levels of tumor necrosis factor-alpha (TNF-alpha) and the inflammatory protein C-reactive protein (CRP), both indicators of increased inflammation. These two levels decreased in those who consumed the low AGE diet.
Researchers note that in animal studies, consuming a reduced AGE diet has been shown to be highly protective in animals genetically predisposed to diabetes.
Proceedings of the National Academy of Sciences Early Edition November 26, 2002; 10,1073/pnas.242437999