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DHEA, a steroid-like supplement version of a naturally occurring
hormone that is often promoted as an anti-aging solution,
does not appear to fight Alzheimer’s disease, according
to a preliminary study.
Previous studies have found the artificial hormone DHEA (dehydroepiandrosterone)
to be helpful for some patients with the autoimmune disease
lupus.
The hormone reaches its highest levels in the body during
a person’s 20s, and scientists have questioned whether
it could play a role in sustaining mental abilities.
It is not known how DHEA functions in the brain, but preliminary
studies in mice have suggested that the hormone may increase
memory.
However, the current study found that DHEA did not statistically
improve mental function among a group of people with Alzheimer’s
disease.
The study involved 28 men and women with Alzheimer’s
disease who took 50 milligrams of DHEA two times each day
and another 30 individuals who took a placebo.
Researchers note that many participants dropped out during
the study, possibly in search of other medications, leaving
19 people in the DHEA group and 14 in the control group at
the end of the study.
After three months, there were small improvements in mental
functioning among participants in the DHEA group, however
the finding was not statistically significant, meaning that
it might have been due to chance.
Researchers concluded that more studies are needed to determine
whether or not DHEA is helpful for people with Alzheimer's
disease.
Neurology
April 8, 2003;60:1060-1061,1071-1076
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