Patients taking selective serotonin reuptake inhibitors (SSRIs), the most commonly prescribed class of antidepressants, may be at an increased risk of suicidal behavior. While there has been previous debate on whether or not antidepressant drugs increase the risk of suicide in some children, recent studies concerning the suicide risk of people over age 18 have widened the possible effect to adults.
In one study, researchers analyzed 345 antidepressant trials for depression and other conditions; the trials involved over 36,000 men and women. The goal was to determine if a link existed between the use of SSRIs and suicide attempts.
The Study Found:
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Over 140 total suicide attempts
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Suicide rate was twice as high in patients taking SSRIs, when compared to those taking placebo (dummy) pills or other forms of therapy, but no more likely to complete the act
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There was no difference between patients taking SSRIs and those taking other antidepressants, such as tricyclics
Such findings--which place taking antidepressants in a negative light--should make doctors aware that SSRIs and tricyclics may evoke or worsen suicidal behavior during the early phases of treatment, prompting closer monitoring of patients. Also, routine prescribing of antidepressants for children and adolescents should be discouraged.
British Medical Journal February 19, 2005; 330:373-374 (free full-text article).
Sarasota Herald-Tribune February 18, 2005
Science Daily February 25, 2005
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