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  • New research revealed that lifetime supplementation with vitamin K, vitamin D3, and calcium is likely to reduce fractures and increase survival in postmenopausal women
  • A vitamin K1, vitamin D3, and calcium combination was found to reduce the lifetime probability of at least one fracture by 20 percent, but adding vitamin K2 to vitamin D3 reduced it by 25 percent
  • If you currently take calcium and vitamin D for your bones, it’s important that you also get plenty of vitamin K2, as these three nutrients have a synergistic effect on your bone (and overall) health
  • One of the best ways to achieve healthy bones is a diet rich in fresh, raw whole foods that maximizes natural vitamins and minerals, fermented foods loaded with vitamin K2, along with healthy sun exposure and regular, weight-bearing exercise

Vitamin K: The Key Vitamin to Use with Vitamin D to Help Reduce Osteoporosis by 25 Percent

May 16, 2012 | 182,851 views
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By Dr. Mercola

You may be aware that vitamin D and calcium are a powerful duo for bone health, including the prevention of osteoporosis. One of the undisputed benefits of vitamin D is that it helps you ABSORB calcium – this link has been known for many decades.

But there is also evidence that vitamin K, and specifically vitamin K2, is another key player in your bone health, and may be just as crucial in helping you prevent bone fractures as you age.

A Powerful Nutrient Trio to Reduce Your Osteoporosis Risk

A study published in Osteoporosis International has concluded that lifetime supplementation with vitamin K1 or, even better, K2, vitamin D3, and calcium is likely to reduce fractures and increase survival in postmenopausal women. Bone loss speeds up most dramatically during the first 10 years after menopause, which is the period when osteoporosis is most likely to develop.

Many are under the mistaken impression that a prescription drug combined with calcium supplements is the answer to strong healthy bones, but the regular consumption of a healthy diet, along with safe sun exposure and extra supplementation when appropriate, is likely to be far superior.

Theorizing that vitamin K might have a role in the primary prevention of fractures, researchers studied the cost-effectiveness of various interventions for preventing fractures in 50-year-old postmenopausal women. They learned that the vitamin K1, vitamin D3, and calcium combination could reduce the lifetime probability of at least one fracture by 20 percent, but adding vitamin K2 to vitamin D3 reduced it by 25 percent.

Vitamin K1 and K2: Which is Better for Your Bones?

In case you weren't aware, vitamin K comes in two forms, and it is important to understand the differences between them before devising your nutritional plan of attack.

  1. Vitamin K1: Found in green vegetables, K1 goes directly to your liver and helps you maintain a healthy blood clotting system. (This is the kind of K that infants need to help prevent a serious bleeding disorder.)
  2. Vitamin K2: Bacteria produce this type of vitamin K. It is present in high quantities in your gut, but unfortunately is not absorbed from there and passes out in your stool. K2 goes straight to vessel walls, bones, and tissues other than your liver.

There are several different forms of vitamin K2: MK4, MK7, MK8, and MK9. The form of vitamin K that has the most relevance for health benefits is MK7, a newer and longer acting form with more practical applications. MK7 is extracted from the Japanese fermented soy product called natto. You could actually get plenty of MK7 from consuming natto, as it is relatively inexpensive and available in most Asian food markets.

Few people, however, easily tolerate its smell and slimy texture, so oftentimes people who find natto unpalatable prefer to take a supplement. Most vitamin K2 supplements are in the form MK7. You can also get MK7 by eating fermented cheeses. There has been some remarkable research about the protective effects of vitamin K2 against osteoporosis:

  • A number of Japanese trials have shown that vitamin K2 completely reverses bone loss and in some cases even increases bone mass in people with osteoporosis.i
  • The pooled evidence of seven Japanese trials show that vitamin K2 supplementation produces a 60 percent reduction in vertebral fractures and an 80 percent reduction in hip and other non-vertebral fractures.ii
  • Researchers in the Netherlands showed that vitamin K2 is three times more effective than vitamin K1 in raising osteocalcin, which controls the building of bone.iii

Why Vitamin K is So Important if You Take Calcium and Vitamin D

If you currently take calcium and vitamin D for your bones, it's important that you also get plenty of vitamin K2. These three nutrients have a synergistic effect that cannot be achieved when one piece of the puzzle is missing. Specifically, here's a simple explanation of why the benefits of calcium and vitamin D are largely dependent on vitamin K:

  • Calcium: There is new evidence that it is vitamin K (specifically, vitamin K2) that directs calcium to your skeleton, while preventing it from being deposited where you don't want it -- i.e., your organs, joint spaces, and arteries. A large part of arterial plaque consists of calcium deposits (atherosclerosis), hence the term "hardening of the arteries."
  • Vitamin K2 activates a protein hormone called osteocalcin, produced by osteoblasts, which is needed to bind calcium into the matrix of your bone. Osteocalcin also appears to help prevent calcium from depositing into your arteries. So while increasing calcium is good for your bones, it is not so good for your arteries, which can become calcified. Vitamin K helps protect your blood vessels from calcifying when in the presence of high calcium levels.

  • Vitamin D3: As mentioned, vitamin D helps your body to absorb calcium, but vitamin K directs that calcium to your skeleton where it's needed. You can think of vitamin D as the gatekeeper, controlling who gets in, and vitamin K as the traffic cop, directing the traffic to where it needs to go. Lots of traffic -- but no traffic cop -- means clogging, crowding and chaos everywhere!
  • In other words, without the help of vitamin K2, the calcium that your vitamin D so effectively lets in might be working AGAINST you -- by building up in your coronary arteries rather than your bones. There is even evidence that the safety of vitamin D is dependent on vitamin K, and that vitamin D toxicity (although very rare with the D3 form) is actually caused by vitamin K2 deficiency.iv

How to Get These Nutrients From Natural Sources

Calcium, vitamin K2 and vitamin D3 are obviously available in supplement form, but you should know that you can also get them naturally from food and the sun.

Calcium, in particular, is better utilized by your body if it's food-based calcium. Good sources include raw milk and cheese from pasture-raised cows (who eat plants), leafy green vegetables, the pith of citrus fruits, carob, sesame seeds and wheatgrass, to name a few. Calcium from dietary sources is typically better absorbed and utilized than calcium from supplements, which may increase your risk of heart attack or stroke.

As for vitamin D3, exposing your skin to natural sunlight is the best way to get enough of this important nutrient. Vitamin D from sunlight acts as a pro-hormone, rapidly converting in your skin into 25-hydroxyvitamin D, or vitamin D3. The next best option is using a safe tanning bed to achieve similar results as that from natural sunlight exposure, and the third best option is taking an oral vitamin D3 supplement whenever natural sun exposure is not an option, then monitoring your levels to be sure you're within the therapeutic range.

Ideally, optimize your vitamin K2 through a combination of dietary sources (leafy green vegetables, fermented foods like natto, raw milk cheeses, etc.) and a K2 supplement, as most people don't get sufficient amounts of vitamin K from their diet to reap its full health benefits. You must use caution with vitamin K if you take anticoagulants, but if you are generally healthy and not on these types of medications, I suggest 150-300 mcg daily.

The Vitamin That Is 'as Good as Drugs' at Reducing Blood Pressure

One of the best parts about optimizing your levels of vitamin D3 is that you will experience a host of beneficial "side effects" – even above and beyond your bone health.

In research presented at the European Society of Hypertension conference in London, scientists studying the effects of vitamin D3 supplementation on heart health reported that they've found that patients with high blood pressure can experience significant improvements in their condition by taking only the supplement, without high-power drugs. The majority of the study's participants were deficient in vitamin D, and while scientists stopped short of recommending vitamin D be substituted for blood pressure drugs, they did say the study shows that supplementation with vitamin D was "as powerful" as the drugs.

Both vitamin D3 and vitamin K2 are important for your heart health, as they work together to increase Matrix GLA Protein (or MGP), the protein responsible for protecting your blood vessels from calcification. In healthy arteries, MGP congregates around the elastic fibers of your tunica media (arterial lining), guarding them against calcium crystal formation.

4 Steps to Help Protect Your Bones No Matter What Your Age …

One of the best ways to achieve healthy bones is a diet rich in fresh, raw whole foods that maximizes natural minerals so that your body has the raw materials it needs to do what it was designed to do. In addition, you need healthy sun exposure along with regular, weight-bearing exercise. To sum it up:

  • Optimize your vitamin D3 either from natural sunlight exposure, a safe tanning bed or an oral vitamin D3 supplement. Check your blood levels regularly to make sure you're within the optimal range.
  • Optimize your vitamin K1 through a combination of dietary sources (leafy green vegetables, fermented foods like natto, raw milk cheeses, etc.) and a K2 supplement, if needed. Although the exact dosing (for oral supplementation) is yet to be determined, and you must use caution on the higher doses if you take anticoagulants, if you are generally healthy and not on these types of medications, I suggest 150-300 mcg daily.
  • Make sure you do weight-bearing exercise, which has profound benefits to your skeletal systems. My favorite is Peak Fitness but it is also very important to do strength-training exercises to produce the dynamic electric forces in your bones that will stimulate the osteoblasts to produce new bone.
  • Consume a wide variety of fresh, local, organic whole foods, including vegetables, nuts, seeds, organic meats and eggs, and raw organic unpasteurized dairy for calcium and other nutrients. The more of your diet you consume RAW, the better nourished you will be. Minimize sugar and refined grains.

How Vitamin D Performance Testing Can Help Optimize Your Health

A robust and growing body of research clearly shows that vitamin D is absolutely critical for good health and disease prevention. Vitamin D affects your DNA through vitamin D receptors (VDRs), which bind to specific locations of the human genome. Scientists have identified nearly 3,000 genes that are influenced by vitamin D levels, and vitamin D receptors have been found throughout the human body.

Is it any wonder then that no matter what disease or condition is investigated, vitamin D appears to play a crucial role? This is why I am so excited about the D*Action Project by GrassrootsHealth. Dr. Heaney is the research director of GrassrootsHealth and is part of the design of the D*action Project as well as analysis of the research findings. GrassrootsHealth shows how you can take action today on known science with a consensus of experts without waiting for institutional lethargy. It has shown how by combining the science of measurement (of vitamin D levels) with the personal choice of taking action and, the value of education about individual measures that one can truly be in charge of their own health.

In order to spread this health movement to more communities, the project needs your involvement. This was an ongoing campaign during the month of February, and will become an annual event.

To participate, simply purchase the D*Action Measurement Kit and follow the registration instructions included. (Please note that 100 percent of the proceeds from the kits go to fund the research project. I do not charge a single dime as a distributor of the test kits.)

As a participant, you agree to test your vitamin D levels twice a year during a five-year study, and share your health status to demonstrate the public health impact of this nutrient. There is a $65 fee every six months for your sponsorship of this research project, which includes a test kit to be used at home, and electronic reports on your ongoing progress. You will get a follow up email every six months reminding you "it's time for your next test and health survey."

Vitamin D Kit
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Where Do We Go From Here?

GrassrootsHealth is now undertaking a new project entitled the Protect our Children NOW! (POC) project. The aim of this project is to acquire participation of at least 500 pregnant women in a community, and to increase their serum levels to the suggested level of at least 40 ng/ml based on the clinical trial by Hollis & Wagner.  In addition, the project will take these results in 2 years and 'march' on the various institutions in the state/government/to the March of Dimes, to demand that action be taken to protect the world's next generation.

Among other items, the projects expected impact is likely to be a reduction in preterm births,(in some cases up to a 50% reduction). The project already has the blessing of the scientists, the physicians at the Medical University of South Carolina (which are implementing it in their practices) and even the insurance company. Any community can implement this and make a difference for themselves and others. For further information contact Jen Aliano, Project Manager, at jen@grassrootshealth.org.

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