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Psychedelic Mushroom Compound Found Nontoxic in Large Study

Analysis by Dr. Joseph Mercola Fact Checked

psilocybin safety

Story at-a-glance -

  • In the largest controlled study of psilocybin to date, conducted at Kings College London, the "magic mushroom" substance was found safe for human consumption
  • A "psychedelic renaissance" is occurring in which the medicinal properties of psilocybin, marijuana and ketamine are being explored
  • Following the large psilocybin safety study, clinical studies will compare the mushroom-derived substance with conventional treatments, such as antidepressants
  • Psilocybin may have usefulness in treating depression, post-traumatic stress disorder, obsessive compulsive disorder, eating disorders and anxiety
  • The FDA has designated psilocybin treatment a "breakthrough therapy," which can fast track a drug's review and approval

There have been rapid changes when it comes to the embracing of psychedelic and hallucinogenic substances by mainstream medicine and municipalities. Marijuana, despite its longtime federal classification as a Schedule I drug, the FDA's most restricted class, is now legal in many U.S. states for medical purposes. States are also increasingly legalizing marijuana for recreational use, as Illinois did in 2020.

Ketamine, a rapid acting anesthetic and established street drug sometimes called "Special K," was approved by the FDA for treating depression last year. And now there are signs that psilocybin, the ingredient in so-called "magic" mushrooms and also classified as a Schedule I drug, may soon be used medically for depression.


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