|
The few souls who brave Antarctic weather may offer clues on treating
wintertime blues in more temperate and populated spots on the planet.
Researchers have found that treatment with
thyroid hormone improves the dulled mental skills and bad moods
that are part of Antarctic life.
Thyroid hormones help orchestrate the body's metabolism. When the
concentration of thyroid hormone in the blood dips too low, metabolism
slows and symptoms such as fatigue, poor memory, weight gain and
depression set in. The condition, called hypothyroidism, is treated
with thyroid hormone.
Since Antarctic living can produce a similar condition called polar
T3 syndrome, investigators looked at whether thyroid hormone might
be useful in the South Pole.
The findings suggest thyroid hormone may combat the "winter
depression" that affects people living in more temperate
climates.
Researchers followed 12 individuals over a year in Antarctica.
The team found that during the first 4
months, the study participants' thyroid hormone levels
dipped, along with their moods and performance on tests of mental
skills and exercise capacity. Their body temperatures had also declined.
Over the next 7 months, half
of the participants took daily doses of thyroid hormone.
By the end of the study, their scores on mental skills tests
had risen and so had their moods.
Researchers believe that living in Antarctica causes the muscles
to hoard thyroid hormone in order to warm the body, at the expense
of the brain. When they gave the individuals thyroid hormone, it
may have been shuttled to the brain, where it was most needed. Thus,
the improvement in mood and mental skills, but not exercise performance.
Thyroid fluctuations have also been found in temperate climates
during winter. This study suggests thyroid supplements should be
studied as a way to combat seasonal affective disorder, a wintertime
depression marked by fatigue, mood swings and concentration problems.
The Journal of Clinical Endocrinology
and Metabolism January 2001;86:110-116
|