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Risks of FluMist Vaccine

October 04, 2003 | 36,296 views
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"MedImmune, the manufacturer of FluMist, recently announced that it signed an agreement that makes FluMist, the new intranasal influenza vaccine, readily available to people as they shop at Wal-Mart, the world's biggest retailer." [1]

As the physician in charge of a bustling integrative medical clinic, questions about vaccines frequently arise. After reading about the MedImmune-Walmart joint venture, I felt compelled to warn our patients and our Internet subscribers of the potentially serious complications that may come from direct and passive exposure to this new vaccine. I also wanted to give a "heads up" to everyone regarding the onslaught of advertising that is about to besiege them.

Hundreds of TV and print advertisements have been designed to persuade everyone into taking the FluMist plunge. The campaign will be the "most intense, direct-to-consumer marketing campaign ever waged for a vaccine," costing an estimated $25 million over the next 2.5 months [2]. In addition, Wyeth, MedImmune's partner, plans a three-year, $100 million campaign to encourage use of the nasal flu vaccine among physicians. [3]

The television arm of the blitz campaign will focus on the "inconveniences" that your family, friends and co-workers will endure if you don't get the flu shot and subsequently contract the flu. Print advertisements and magazine articles apparently will use scare tactics--similar to those that were used while promoting the smallpox vaccine--which warned of the high possibility of a "bioterror attack using the flu virus."[4]

Apparently, the goal seems to center around frightening--or inducing enough guilt--so that everyone would begin to demand the vaccine as soon as it is available. And at nearly $70 a dose, this will be a financial bonanza for MedImmune and Wyeth, who are expecting the vaccine to become the blockbuster new drug that will push MedImmune's revenues to more than $1 billion/year. [5]

However, there are many reasons for caution. FluMist contains live (attenuated) influenza viruses that replicate in the nasopharynx of the vaccine recipient. The most common side effects include "cough, runny nose/nasal congestion, irritability, headaches, chills, muscle aches and fever > 100° F."Devil These symptoms are nearly identical to those the flu vaccine is designed to prevent. [7]

A cause for significant concern is the vaccine's most prevalent side effects: "runny nose" and "nasal congestion." It has been documented that the live viruses from the vaccine can be shed (and potentially spread into the community) from recipient children for up to 21 days, Music and even longer from adults. [9] Viral shedding also puts breastfeeding infants at risk if the mother has been given FluMist. [10]

In addition to shedding via nasal secretions, the virus can be dispersed through sneezing. What is the normal physiological response when an irritant enters the nasal passages? A sneeze ... sometimes a big sneeze ... sometimes several big sneezes. Therefore, the risk for shedding--and spreading--live viruses throughout a school, church, workplace or store--especially one which is administering the vaccine.

In the section of the FluMist package insert labeled "PRECAUTIONS," the manufacturer states the following warning:

"FluMist® recipients should avoid close contact with
immunocompromised individuals for at least 21 days."

The warning is specifically directed toward those living in the same household with an immunocompromised person, but the on-going release of live viruses throughout the community may be a significant risk to everyone who has a weak, or weakened, immune system.

The number of immunocompromised people in the United States is enormous:

  • It is estimated that at least 10 percent, or more than 28 million people have eczema. [11]
  • More than 8.5 million people have cancer. [12]
  • There are reported to be 850,000 individuals with diagnosed and undiagnosed HIV infection or AIDS [13]
  • Based on 2001 data, there were 184,000 organ recipients [14]

An even more extensive list of at-risk people includes the untold millions on drugs called corticosteroids. Prednisone®, Medrol®, and a variety of similar medications given to both adults and children. These drugs are prescribed for dozens of conditions including asthma, allergies, eczema, emphysema, Crohn's disease, multiple sclerosis, herniated spinal discs, acute muscular pain syndromes, and all types of rheumatoid and autoimmune diseases. As much as 60 percent of the entire population could be considered to be "chemically immunosuppressed." It is important to realize that FluMist is CONTRAINDICATED for people who are immunocompromised. People who receive FluMist and are living with an immunocompromised person put their loved ones at risk.

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Will this make stores that administer the vaccines--like Walmart and the other pharmaceutical chain stores that have announced they will carry FluMist [15]--risky places to shop for large segments of the population? What measures will be taken in these stores to ensure that the virus will not become commingled with food? What hand washing policy is going to be enforced in the stores for all Walmart employees and customers who have received FluMist? These are reasonable questions that deserve answers.

The target market for FluMist is "healthy children and adults, ages 5 to 49 years." Some believe that by vaccinating these people, a type of "herd immunity" will occur that will protect the very young and the elderly who are excluded from getting this vaccine. However, it is these very "at-risk" populations who may suffer the most from the flu by being exposed to people who are given FluMist.

According to information presented at the May 2003 National Influenza Summit, [16] approximately 85 percent of Americans between the ages of 20 and 50 go unvaccinated, and nearly 66 percent between the ages of 50 and 64 do not receive the flu vaccine. Have there been "raging epidemics" across the country due to lack of flu vaccinations? It appears that the massive campaign to vaccinate everyone this year may be motivated, in part, by economics.

The viruses suspected to be the most likely cause for the flu this season were negligibly different from the strains used in last year's flu vaccine. Therefore, the influenza vaccine produced for the 2003-2004 season is identical in composition to the one used last year. This marks only the second time that the same strains have been used during two consecutive flu seasons. [17] Consider that antibodies from other viral vaccines--such as MMR, polio and chickenpox vaccines--last at least three years, and in some instances, up to 15 years. If the viruses used in the vaccine are the same as last year, why is this year's vaccine even necessary?

An even greater concern about FluMist is the contents within the vaccine. Each 0.5 ml of the formula contains 10 6.5-7.5 particles of live, attenuated influenza virus. That means that between 10 million and 100 million viral particles will be forcefully injected into the nostrils when administered. The viral strain was developed by serial passage through "specific pathogen-free primary chick kidney cells" and then grown in "specific pathogen-free eggs." That means that the culture media was free of pathogens that were specifically tested for, but not a culture that was necessarily "pathogen-free." The risk that the vaccine may contain contaminant avian retroviruses still remains. In addition, a stabilizing buffer containing potassium phosphate, sucrose (table sugar) and nearly 0.5 mg of monosodium glutamate (MSG) is added to each dose. [18]

One of the most troubling concerns over the injection of this "chemical soup" is the potential for the viruses to enter directly into the brain. At the top of the nasal passages is a paper-thin bone called the cribriform plate. The olfactory nerves pass through this bone and line the nasal passages, carrying messenger molecules to the brain that are identified as "smells" familiar to us. The olfactory tract has long been recognized as a direct pathway to the brain. Intranasal injection of certain viruses has resulted in a serious brain infection called encephalitis, presumably by direct infection of the olfactory neurons that carried the viruses to the brain. [19] Time will tell whether the live viruses in FluMist will become linked to cases of encephalitis.

The pharmaceutical companies do not necessarily always do a reasonable job of considering the "down side" when they are pushing new drugs or new vaccines. FluMist has the potential for causing the worst, most severe flu epidemic seen in years. Parents tell their young children not to put things up their noses because they might cause them harm. It would be wise to consider that advice for adults. With all the risks involved, one should be extremely cautious about what one allows to be sprayed in one's nose.

Red Flags Weekly October 3, 2003

 

Dr. Mercola's Comments:


Dr. Mercola's Comment:

Long-time readers may remember that three years ago I warned this live flu spray vaccine was coming, and it has finally arrived.

The "experts" will use fear to motivate people to get a flu vaccine, but this is yet another health care illusion. Let's be clear, flu can definitely be a killer disease and is not something that should be easily dismissed. But, remember that flu shots don't prevent illness--never have, never will.

The flu vaccine can actually weaken the immune system and make you more predisposed to the illness. And as the above article says, the side effects of FluMist sound just like the symptoms of the flu. If you decide to get this nasal vaccine, you will get not only a live flu virus in each dose but also table sugar and MSG, which are fraught with their own problems.

Just remember, the flu vaccine is not the answer to avoiding the flu.

People are dying from the flu because they are already sick and have compromised immune systems. The majority of the cause is surely related to eating too much sugar and too many grains, getting inadequate rest and suffering from unresolved emotional trauma.

I provide the entire means to optimize your immune system (and increase energy, avoid premature aging and optimize weight) in my new book, Dr. Mercola's Total Health Program. In this book, you will learn all about the dangers of grains and sugars, and ALL of the healthiest foods you should be eating. Plus, you'll learn your own "metabolic type," so you will also learn how to eat the right PROPORTION of carbs, proteins and fats that are ideal for your particular biochemistry. You'll also learn all about the importance of emotional health, and how to achieve it (and of course you get over 150 brand-new delicious and highly nutritious recipes). This book IS the means to your optimal immune system, so you won't have to worry about vaccinations, so read more about it now (including the book's lifetime guarantee).

Naturally, if you are healthy you will likely never get the flu, but if you do there are some simple strategies that you can follow that will be highly beneficial. One is to try the inexpensive and non-toxic hydrogen peroxide treatment.

Related Articles:

Nasal Spray Flu Vaccine Ready for Launch

Spray Vaccine for Flu Wins FDA Clearance

Vaccine Revenues Expected to Reach $10 Billion by 2006

Flu Now Kills More Americans Than AIDS

Why I Never Get Flu Shots

Flu Shot is Not Cost Effective For Adults But is For Children?


References

  1. DowJones Business News. Sept. 12, 2003. FluMist Available In Pharmacies This Fall.

  2. Washington Post. Nasal spray for flu to get big media launch. Sept. 10, 2003, pg. E01

  3. Washington Post. Spray vaccine for flu wins FDA clearance. June 18, 2003. pg. A01.

  4. Mohammed, Madjid. Influenza as a bioweapon. J.R.Soc.Med. 2003;96:345-346.

  5. Adler, Neil. MedImmune awaits the $1 billion mark and a new flu drug. The Business Gazette. Feb. 7, 2003. http://www.gazette.net

  6. FluMist package insert.

  7. Vesikari T., et al. A randomized, double-blind, placebo-controlledtrial of the safety, transmissibility and phenotypic stability of a live, attenuated, cold-adapted influenza virus vaccine (CAIV-T) in children attending day care. Presented at the 41st Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, (Chicago, IL). 2001

  8. ibid. (Chicago, IL). 2001

  9. Zangwell, Kenneth. Cold-adapted, live attenuated intranasal influenza virus vaccine. The Pediatric Infectious Disease Journal 2003; 22(3):273-274.

  10. Drug information. http://www.nlm.nih.gov

  11. Diepgen TL. Is the prevalence of atopic dermatitis increasing? In: Williams HC, ed. Atopic Dermatitis: The Epidemiology, Causes and Prevention of Atopic Eczema. New York: Cambridge Univ Pr; 2000:96-112.

  12. National Cancer Institute. CanQues. Available at http://srab. cancer.gov/Prevalence/canques.html. Accessed January 3, 2002.

  13. Joint United Nations Programme on HIV/AIDS. Epidemiological Fact Sheets on HIV and Sexually Transmitted Infections: United States. Accessed January 14, 2002

  14. United Network for Organ Sharing (UNOS). All Recipients: Age at Time of Transplant. Available at http://www.unos.org. Accessed January 14, 2002.

  15. Allan and Harold Rubin, MS, ABD, CRC. September 26, 2003. Vaccinations and the Elderly. http://www.therubins.com

  16. May 20-21, 2003, the National Influenza Summit. Chicago, IL. http://www.partnersforimmunization.org

  17. ibid.

  18. FluMist package insert.

  19. Knipe, David. M. Ed. Fields Virology. Philadelpthis: Lippincott, 4th ed. 2001. pg. 1057


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