University researchers found that the reward value of food increases
for some smokers when they quit. These smokers have a genetic factor
that causes the reaction, which leads to weight gain in the six
months following cessation.
Experts say the results of this study are key in proving an association
between desire for food and genes.
Researchers examined the rewarding value of food for 71 smokers
enrolled in a clinical trial of bupropion. Some were given the smoking
cessation drug and some were given a placebo; all received group
counseling. Team members recorded smoking status, abstinence symptoms
and side effects on a weekly basis. At the end of treatment and
at a six-month follow-up appointment, smoking status and weight
were recorded again.
Participants were also required to give blood samples and take
part in two behavioral sessions to evaluate rewarding values of
food.
Looking at both types of dopamine D2 receptor genes, researchers
found that participants with the less common kind showed significant
increase in the rewarding value of food after they quit smoking,
but those that were taking bupropion did not gain much weight.
This suggests that bupropion may be an effective treatment for
smokers who are more likely to experience increases in food reward
and subsequent weight gain after quitting.
Science
Daily September 9, 2004
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