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Grape-Derived Compounds to Help Beat Depression

grape seed extract depression

Story at-a-glance -

  • A polyphenol preparation made from Concord grape juice, grape seed extract and trans-resveratrol has shown promise for treating depression
  • Two phytochemicals in particular — dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc) — appeared to be responsible for the beneficial effects
  • The grape-derived compounds target cellular and molecular pathways associated with inflammation while modulating synaptic plasticity, disruptions of which have been linked to depression

By Dr. Mercola

A polyphenol preparation made from Concord grape juice, grape seed extract and trans-resveratrol has shown promise for treating depression, according to an animal study from the Icahn School of Medicine at Mount Sinai. Two phytochemicals in particular — dihydrocaffeic acid (DHCA) and malvidin-3'-O-glucoside (Mal-gluc) — appeared to be responsible for the beneficial effects, which included modulating inflammation and synaptic plasticity, essentially increasing resilience against stress-induced depression in mice.


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