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5-HTP Is Helpful for Mitochondrial Biogenesis

Analysis by Dr. Joseph Mercola Fact Checked

5 htp for mitochondrial biogenesis

Story at-a-glance -

  • Researchers in Mumbai, India, found that the neurotransmitter serotonin, aka 5-HT, is a significant player in producing new mitochondria in neurons, a process called mitochondrial biogenesis
  • Mitochondria are the “powerhouses” that generate energy, optimize cellular function and regulate the survival of neurons, especially under stress
  • Mitochondrial biogenesis enhances mitochondrial function in a number of ways that protect the neurons of your brain, including the involvement of serotonin-2A, also known as 5-HT2A
  • 5-HTP, the hydroxylated form of tryptophan, is made from the seeds of the African plant Griffonia simplicifolia and isn’t derived from foods
  • Studies show that while the jury is still out on 5-HTP’s efficacy for anxiety and depression, it has been found very effective for weight loss, sleep disorders, pain from fibromyalgia and migraines, and more

Because the metaphor is so apt, mitochondria are often referred to as the "powerhouses" that generate energy, optimize cellular function and regulate the survival of neurons, especially under stress. Then a recent study uncovered more.

Teams of researchers based at Tata Institute of Fundamental Research (TIFR) in Mumbai, India, found that the neurotransmitter serotonin, known in scientific circles as 5-HT, is a significant player in the creation of new mitochondria in neurons, a process called mitochondrial biogenesis.


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