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According to results of a new study, children who gain a lot of weight in the first year of life may be at increased risk of type 1 diabetes. To summarize:
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The study included 91 children aged 4 to 15 with type 1 diabetes, 125 of their siblings, and more than 2,000 healthy Dutch children.
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The researchers analyzed their past health records and found that children who became diabetic tended to gain more weight by the age of 1 than their siblings or other children.
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The diabetic children and their healthy siblings also tended to be taller between the ages of 1 and 3 compared with children in the general population.
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The investigators also found the children with diabetes who were heavier and taller at a young age tended to have a specific type of autoantibody, which is antibody that mistakenly recognizes an enzyme normally found in the insulin-producing cells of the pancreas.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly destroys the pancreatic cells that produce insulin. As a result, blood glucose levels rise to dangerous levels, resulting in a life-long dependence on insulin injections for survival. The disease is most commonly diagnosed in children or young adults, and therefore is often referred to as Juvenille diabetes, despite the fact that it can occur at any age.
The authors believe that increased growth in infancy, which is associated with a higher insulin secretion, could lead to more rapid decay of insulin-producing cells if the antibodies develop.
The Lancet 2000;356:655-656.
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