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US transplant centers
aren't just considering Type 1 diabetics when they review
transplant cases - they are picking the most robust candidates,
the ones most likely to survive the transplant process. These
candidates can sometimes include Type 2 diabetics.
The researchers
surveyed 44 transplant centers in the US and found that of
all the transplant recipients in 1999, fewer than 2 percent
were Type 2 diabetics. This percentage is notable because
Type 2 diabetics are not typically considered for transplants,
since it can be effectively maintained through other means.
Type 1 diabetics
are more likely to receive transplants because their version
of the disease typically shows up in childhood, from an immune
system attack on the pancreatic cells that produce insulin.
What role does
insulin play in type 1 and 2 diabetes?
Insulin is an important
hormone in the body. Insulin is necessary for the body to
be able to use sugar. Sugar is the basic fuel for the cells
in the body, and insulin takes the sugar from the blood into
the cells. When glucose builds up in the blood instead of
going into cells, it can cause two problems:
- Right away,
your cells may be starved for energy.
- Over time, high
blood glucose levels may hurt your eyes, kidneys, nerves
or heart.
In type 2 diabetes,
either the body does not produce enough insulin or the cells
ignore the insulin. In type 1 diabetes, the body does not
produce insulin.
How do people
get type 1 diabetes?
In type
1 diabetes, the pancreas, an organ near your stomach,
produces insulin. The pancreas contains cells called beta
cells. Beta cells have a vital job: They make insulin, a hormone
that helps cells take in the sugar they need. Sometimes, the
beta cells get wiped out and cannot produce insulin anymore.
Many things might
have killed your beta cells, but in most people with type
1 diabetes, the immune system makes a mistake. Cells that
normally protect you from germs attack your beta cells instead.
The beta cells die and you can't make insulin. Sugar builds
up in your blood, and you get diabetes. In some cases, a new
pancreas -- or a transplant of insulin-producing pancreatic
cells -- can help control the disease.
How do people
get type 2 diabetes?
In type 2 diabetes
by far the more common form, the pancreas is usually producing
insulin, but the body cannot use it properly. The condition
is closely associated with obesity and is most often seen
in middle-aged and older adults.
Diabetes
Care October 2002;25:1896
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